Department of Neuropsychiatry, Unit of Translation Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
Yuzuriha Hospital Pharmacy, Nagasaki, Japan.
J Neural Transm (Vienna). 2020 Nov;127(11):1491-1499. doi: 10.1007/s00702-020-02212-z. Epub 2020 May 25.
Although it is clear that nutrition affects physical and metabolic functions in humans, the importance of nutrition in mental illness has often been overlooked. Following a report by Hibbeln (Lancet 351:1213, 1998) published in The Lancet, which suggested that depression rates and fish consumption were inversely correlated, the relationships between a variety of nutritional/epidemiological treatments and neuropsychiatric disorders have received increased attention. In particular, many studies have been conducted on the omega-3 fatty acid mechanism of action in pathophysiological aspects of various neuropsychiatric disorders. Furthermore, many clinical studies have also been conducted on the effects of omega-3 replacement therapy. Therefore, this article reports recent trends in, and perspectives on, the use of omega-3 fatty acids to treat the five psychiatric disorders: schizophrenia (a delusion of the psychotic zone), depression and other mood disorders, attention deficit hyperactivity disorder (a developmental disorder), post-traumatic stress disorder (psychological trauma after the disaster), and Alzheimer-type dementia.
虽然营养对人类的身体和代谢功能有明显的影响，但营养在精神疾病中的重要性常常被忽视。在 Hibbeln（ Lancet 351:1213, 1998）在《柳叶刀》上发表的一份报告之后，该报告表明抑郁率与鱼类消费呈负相关，各种营养/流行病学治疗与神经精神疾病之间的关系受到了更多的关注。特别是，许多研究已经针对各种神经精神疾病的病理生理方面的ω-3 脂肪酸作用机制进行了研究。此外，许多临床研究也已经针对ω-3 替代疗法的效果进行了研究。因此，本文报告了使用ω-3 脂肪酸治疗五种精神障碍的最新趋势和观点：精神分裂症（精神病区的妄想），抑郁症和其他情绪障碍，注意缺陷多动障碍（发育障碍），创伤后应激障碍（灾难后的心理创伤）和阿尔茨海默氏型痴呆症。
