Instituto de Ganadería de Montaña (CSIC-Universidad de León), Grulleros, León, Spain.
Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad de León, Campus de Vegazana, León, Spain.
Vet Pathol. 2020 Jul;57(4):545-549. doi: 10.1177/0300985820923987. Epub 2020 May 26.
Early abortion in ovine toxoplasmosis has had limited investigation. This study evaluated the immune response in the placenta of sheep orally infected with and euthanized between 2 and 4 weeks postinfection. infection of the placenta was only found at 4 weeks after infection. Parasitic debris in foci of necrosis were immunolabeled in the maternal caruncle, whereas well-preserved intracellular parasitic vacuole-like structures were found in trophoblasts of fetal cotyledon. Early abortions had increased macrophages in caruncular septa, whereas in later abortions the placentas containing the parasite had an increase of T lymphocytes and macrophages mainly in the fetal cotyledons. This study suggests that the immune response in both the fetal and maternal compartments of the placenta may contribute to the pathogenesis of ovine toxoplasmosis and that these responses differ between early and late presentations of the disease.
绵羊弓形虫病的早期流产研究有限。本研究评估了经口感染弓形虫并在感染后 2 至 4 周内安乐死的绵羊胎盘的免疫反应。仅在感染后 4 周发现胎盘感染。坏死灶中的寄生虫碎片在母体肉阜中被免疫标记，而在胎儿绒毛膜的滋养层中则发现保存完好的细胞内似空泡状寄生虫结构。早期流产的肉阜隔中有更多的巨噬细胞，而在晚期流产中含有寄生虫的胎盘则有更多的 T 淋巴细胞和巨噬细胞，主要在胎儿绒毛膜中。本研究表明，胎盘胎儿和母体部分的免疫反应可能有助于绵羊弓形虫病的发病机制，并且这些反应在疾病的早期和晚期表现之间有所不同。
