School of Pharmacy, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.
Curr Pharm Des. 2020;26(27):3203-3217. doi: 10.2174/1381612826666200526145706.
Solid lipid nanoparticles (SLNs) have shown potential as a novel lipid-based drug delivery system for the topical applications of innumerable therapeutic compounds. However, the mechanisms governing the absorption and cellular uptake of SLNs through topical route, along with the mechanism of drug release from SLNs are still ambiguous, and require further investigation. In addition, the selection of an appropriate dosage form/formulation base is essential for ease of application of SLNs and to enhance dermal and transdermal delivery. Upscaling and regulatory approvals are other challenges that may impede the clinical translation of SLNs. Therefore, this review focusses on different mechanisms involved in skin penetration and cellular uptake of SLNs. This is followed by a comprehensive discussion on the physicochemical properties of SLNs including various formulation and dosage form factors, which might influence the absorption of SLNs through the skin. Finally, translational status with respect to scale-up and regulatory aspects are also discussed. This review will be useful to researchers with an interest in topical applications of SLNs for the efficient delivery of drugs and cosmetics.
固体脂质纳米粒（SLN）作为一种新型的基于脂质的药物传递系统，在众多治疗化合物的局部应用中显示出潜力。然而，通过局部途径控制 SLN 的吸收和细胞摄取的机制，以及 SLN 中药物释放的机制仍然不清楚，需要进一步研究。此外，选择合适的剂型/制剂基础对于 SLN 的应用方便性以及增强皮肤和经皮给药至关重要。扩大规模和监管批准是可能阻碍 SLN 临床转化的其他挑战。因此，本综述重点讨论了 SLN 经皮渗透和细胞摄取涉及的不同机制。接下来，全面讨论了 SLN 的物理化学性质，包括各种制剂和剂型因素，这些因素可能会影响 SLN 通过皮肤的吸收。最后，还讨论了关于扩大规模和监管方面的转化状态。对于有兴趣将 SLN 应用于局部递药以高效传递药物和化妆品的研究人员来说，这篇综述将非常有用。
