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First evidence that senolytics are effective at decreasing senescent cells in humans.

作者信息

Ellison-Hughes Georgina M

机构信息

School of Basic and Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom.

出版信息

EBioMedicine. 2020 Jun;56:102473. doi: 10.1016/j.ebiom.2019.09.053. Epub 2020 May 23.

DOI:10.1016/j.ebiom.2019.09.053

PMID:32454400

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7248649/

Abstract

摘要

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本文引用的文献

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease.

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Aging Cell. 2019 Jun;18(3):e12931. doi: 10.1111/acel.12931. Epub 2019 Mar 10.

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study.

EBioMedicine. 2019 Feb;40:554-563. doi: 10.1016/j.ebiom.2018.12.052. Epub 2019 Jan 5.

Fisetin is a senotherapeutic that extends health and lifespan.

EBioMedicine. 2018 Oct;36:18-28. doi: 10.1016/j.ebiom.2018.09.015. Epub 2018 Sep 29.

Aging, Cell Senescence, and Chronic Disease: Emerging Therapeutic Strategies.

JAMA. 2018 Oct 2;320(13):1319-1320. doi: 10.1001/jama.2018.12440.

Senolytics improve physical function and increase lifespan in old age.

Nat Med. 2018 Aug;24(8):1246-1256. doi: 10.1038/s41591-018-0092-9. Epub 2018 Jul 9.

The Clinical Potential of Senolytic Drugs.

J Am Geriatr Soc. 2017 Oct;65(10):2297-2301. doi: 10.1111/jgs.14969. Epub 2017 Sep 4.

Cellular Senescence: A Translational Perspective.

EBioMedicine. 2017 Jul;21:21-28. doi: 10.1016/j.ebiom.2017.04.013. Epub 2017 Apr 12.

Cellular senescence in aging primates.

Science. 2006 Mar 3;311(5765):1257. doi: 10.1126/science.1122446. Epub 2006 Feb 2.

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相似文献

First evidence that senolytics are effective at decreasing senescent cells in humans.

EBioMedicine. 2020 Jun;56:102473. doi: 10.1016/j.ebiom.2019.09.053. Epub 2020 May 23.

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors.

Aging Cell. 2016 Jun;15(3):428-35. doi: 10.1111/acel.12445. Epub 2016 Mar 18.

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease.

EBioMedicine. 2019 Sep;47:446-456. doi: 10.1016/j.ebiom.2019.08.069. Epub 2019 Sep 18.

The Achilles' heel of senescent cells: from transcriptome to senolytic drugs.

Aging Cell. 2015 Aug;14(4):644-58. doi: 10.1111/acel.12344. Epub 2015 Apr 22.

Quercetin and dasatinib, two powerful senolytics in age-related cardiovascular disease.

Biogerontology. 2024 Feb;25(1):71-82. doi: 10.1007/s10522-023-10068-5. Epub 2023 Sep 25.

New agents that target senescent cells: the flavone, fisetin, and the BCL-X inhibitors, A1331852 and A1155463.

Aging (Albany NY). 2017 Mar 8;9(3):955-963. doi: 10.18632/aging.101202.

Virus-induced senescence is a driver and therapeutic target in COVID-19.

Nature. 2021 Nov;599(7884):283-289. doi: 10.1038/s41586-021-03995-1. Epub 2021 Sep 13.

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Biogerontology. 2024 Aug;25(4):691-704. doi: 10.1007/s10522-024-10103-z. Epub 2024 Apr 15.

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Nat Med. 2018 Aug;24(8):1246-1256. doi: 10.1038/s41591-018-0092-9. Epub 2018 Jul 9.

引用本文的文献

Assessing the Effects of Dasatinib on Mesenchymal Stem/Stromal Cells.

Cell Mol Bioeng. 2024 Oct 29;17(6):609-618. doi: 10.1007/s12195-024-00830-1. eCollection 2024 Dec.

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Aging Dis. 2023 Nov 29;15(6):2595-2631. doi: 10.14336/AD.2023.1128.

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Effect of Cellular Senescence in Disease Progression and Transplantation: Immune Cells and Solid Organs.

Transplantation. 2024 Jul 1;108(7):1509-1523. doi: 10.1097/TP.0000000000004838. Epub 2023 Nov 13.

[Skin aging-cellular senescence : What is the future?].

Dermatologie (Heidelb). 2023 Sep;74(9):645-656. doi: 10.1007/s00105-023-05201-x. Epub 2023 Aug 28.

Fisetin Attenuates Cellular Senescence Accumulation During Culture Expansion of Human Adipose-Derived Stem Cells.

Stem Cells. 2023 Jul 14;41(7):698-710. doi: 10.1093/stmcls/sxad036.

Therapeutic Potential of a Senolytic Approach in a Murine Model of Chronic GVHD.

Biology (Basel). 2023 Apr 25;12(5):647. doi: 10.3390/biology12050647.

本文引用的文献

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease.

EBioMedicine. 2019 Sep;47:446-456. doi: 10.1016/j.ebiom.2019.08.069. Epub 2019 Sep 18.

Aged-senescent cells contribute to impaired heart regeneration.

Aging Cell. 2019 Jun;18(3):e12931. doi: 10.1111/acel.12931. Epub 2019 Mar 10.

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study.

EBioMedicine. 2019 Feb;40:554-563. doi: 10.1016/j.ebiom.2018.12.052. Epub 2019 Jan 5.

Fisetin is a senotherapeutic that extends health and lifespan.

EBioMedicine. 2018 Oct;36:18-28. doi: 10.1016/j.ebiom.2018.09.015. Epub 2018 Sep 29.

Aging, Cell Senescence, and Chronic Disease: Emerging Therapeutic Strategies.

JAMA. 2018 Oct 2;320(13):1319-1320. doi: 10.1001/jama.2018.12440.

Senolytics improve physical function and increase lifespan in old age.

Nat Med. 2018 Aug;24(8):1246-1256. doi: 10.1038/s41591-018-0092-9. Epub 2018 Jul 9.

The Clinical Potential of Senolytic Drugs.

J Am Geriatr Soc. 2017 Oct;65(10):2297-2301. doi: 10.1111/jgs.14969. Epub 2017 Sep 4.

Cellular Senescence: A Translational Perspective.

EBioMedicine. 2017 Jul;21:21-28. doi: 10.1016/j.ebiom.2017.04.013. Epub 2017 Apr 12.

Cellular senescence in aging primates.

Science. 2006 Mar 3;311(5765):1257. doi: 10.1126/science.1122446. Epub 2006 Feb 2.

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First evidence that senolytics are effective at decreasing senescent cells in humans.

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