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表现为色素沉着和闭经的2型自身免疫性多腺体综合征。

Type 2 Autoimmune Polyglandular Syndrome Presenting with Hyperpigmentation and Amenorrhea.

作者信息

Gaba Nayana, Gaba Saurabh, Singla Mandeep, Gupta Monica

机构信息

Obstetrics and Gynaecology, Postgraduate Institute of Medical Education and Research, Chandigarh, IND.

Internal Medicine, Government Medical College and Hospital, Chandigarh, IND.

出版信息

Cureus. 2020 Apr 21;12(4):e7772. doi: 10.7759/cureus.7772.

DOI:10.7759/cureus.7772
PMID:32455083
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7243617/
Abstract

A 36-year-old female presented with lethargy, anorexia, nausea, hyperpigmentation, weight loss and amenorrhea for six months. On examination, she had hyperpigmentation of face, hands and oral mucosa. Investigations revealed adrenal insufficiency and subclinical hyperthyroidism with elevated anti-thyroid peroxidase antibodies. Adrenal insufficiency in combination with Grave's disease and/or type 1 diabetes mellitus occurs in type 2 autoimmune polyglandular syndrome. It is a polygenic disorder occurring due to mutations in the human leukocyte antigen complex on chromosome 6. The patient was treated with oral hydrocortisone which led to improvement in all the symptoms.

摘要

一名36岁女性出现乏力、厌食、恶心、色素沉着、体重减轻和闭经6个月。检查时，她面部、手部和口腔黏膜有色素沉着。检查发现肾上腺功能不全以及抗甲状腺过氧化物酶抗体升高的亚临床甲状腺功能亢进。肾上腺功能不全合并格雷夫斯病和/或1型糖尿病见于2型自身免疫性多腺体综合征。它是一种多基因疾病，由6号染色体上人类白细胞抗原复合体的突变引起。该患者接受口服氢化可的松治疗后，所有症状均有改善。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e59c/7243617/1afc5940cad7/cureus-0012-00000007772-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e59c/7243617/2787665ec81d/cureus-0012-00000007772-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e59c/7243617/3bba6625a67a/cureus-0012-00000007772-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e59c/7243617/1afc5940cad7/cureus-0012-00000007772-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e59c/7243617/2787665ec81d/cureus-0012-00000007772-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e59c/7243617/3bba6625a67a/cureus-0012-00000007772-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e59c/7243617/1afc5940cad7/cureus-0012-00000007772-i03.jpg

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1
Novel medications inducing adrenal insufficiency.
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2
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Ther Adv Endocrinol Metab. 2019 Jun 13;10:2042018819848218. doi: 10.1177/2042018819848218. eCollection 2019.
3
Clinical course of thyroid function and thyroid associated-ophthalmopathy in patients with euthyroid Graves' disease.甲状腺功能正常的Graves病患者的甲状腺功能及甲状腺相关性眼病的临床病程
Clin Ophthalmol. 2018 Apr 19;12:739-746. doi: 10.2147/OPTH.S158967. eCollection 2018.
4
Group 1. Epidemiology of primary and secondary adrenal insufficiency: Prevalence and incidence, acute adrenal insufficiency, long-term morbidity and mortality.第一组：原发性和继发性肾上腺功能不全的流行病学：患病率和发病率、急性肾上腺功能不全、长期发病率和死亡率。
Ann Endocrinol (Paris). 2017 Dec;78(6):490-494. doi: 10.1016/j.ando.2017.10.010. Epub 2017 Nov 27.
5
Polyglandular autoimmune syndromes.自身免疫性多腺体综合征。
J Endocrinol Invest. 2018 Jan;41(1):91-98. doi: 10.1007/s40618-017-0740-9. Epub 2017 Aug 17.
6
Risk Factors for Graves' Orbitopathy; the Australian Thyroid-Associated Orbitopathy Research (ATOR) Study.格雷夫斯眼病的风险因素；澳大利亚甲状腺相关眼病研究（ATOR）。
J Clin Endocrinol Metab. 2016 Jul;101(7):2711-20. doi: 10.1210/jc.2015-4294. Epub 2016 Apr 7.
7
Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline.原发性肾上腺皮质功能减退症的诊断与治疗：内分泌学会临床实践指南
J Clin Endocrinol Metab. 2016 Feb;101(2):364-89. doi: 10.1210/jc.2015-1710. Epub 2016 Jan 13.
8
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Nucl Med Rev Cent East Eur. 2015;18(2):110-6. doi: 10.5603/NMR.2015.0026.
9
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Int J Endocrinol Metab. 2012 Spring;10(2):490-6. doi: 10.5812/ijem.3447. Epub 2012 Apr 20.
10
Clinical, immunological, and genetic features of autoimmune primary adrenal insufficiency: observations from a Norwegian registry.自身免疫性原发性肾上腺功能不全的临床、免疫和遗传特征：来自挪威登记处的观察结果。
J Clin Endocrinol Metab. 2009 Dec;94(12):4882-90. doi: 10.1210/jc.2009-1368. Epub 2009 Oct 26.