Cohan Megan C, Pappu Rohit V
Department of Biomedical Engineering and Center for Science and Engineering of Living Systems (CSELS), Washington University in St. Louis, St. Louis, MO 63130, USA.
Department of Biomedical Engineering and Center for Science and Engineering of Living Systems (CSELS), Washington University in St. Louis, St. Louis, MO 63130, USA.
Trends Biochem Sci. 2020 Aug;45(8):668-680. doi: 10.1016/j.tibs.2020.04.011. Epub 2020 May 23.
Intrinsically disordered proteins/regions (IDPs/IDRs) contribute to a diverse array of molecular functions in eukaryotic systems. There is also growing recognition that membraneless biomolecular condensates, many of which are organized or regulated by IDPs/IDRs, can enable spatial and temporal regulation of complex biochemical reactions in eukaryotes. Motivated by these findings, we assess if (and how) membraneless biomolecular condensates and IDPs/IDRs are functionally involved in key cellular processes and molecular functions in bacteria. We summarize the conceptual underpinnings of condensate assembly and leverage these concepts by connecting them to recent findings that implicate specific types of condensates and IDPs/IDRs in important cellular level processes and molecular functions in bacterial systems.
内在无序蛋白质/区域（IDPs/IDRs）在真核系统中发挥着多种分子功能。人们也越来越认识到，无膜生物分子凝聚物（其中许多由IDPs/IDRs组织或调控）能够实现真核生物中复杂生化反应的时空调节。受这些发现的启发，我们评估无膜生物分子凝聚物和IDPs/IDRs是否（以及如何）在细菌的关键细胞过程和分子功能中发挥功能作用。我们总结了凝聚物组装的概念基础，并通过将这些概念与最近的发现联系起来，利用这些概念，这些发现表明特定类型的凝聚物和IDPs/IDRs参与了细菌系统中重要的细胞水平过程和分子功能。
