Tianjiu Research and Development Center for Exercise Nutrition and Foods, Hubei Key Laboratory of Exercise Training and Monitoring, College of Health Science, Wuhan Sports University, Wuhan 430079, China.
Graduate School, Wuhan Sports University, Wuhan 430079, China.
Pharmacol Res. 2020 Sep;159:104943. doi: 10.1016/j.phrs.2020.104943. Epub 2020 May 24.
Spermidine, as a natural component from polyamine members, is originally isolated from semen and also existed in many natural plants, and can be responsible for cell growth and development in eukaryotes. The supplementation of spermidine can extend health and lifespan across species. Although the elevated levels of polyamines and the regulation of rate-limiting enzymes for polyamine metabolism have been identified as the biomarkers in many cancers, recent epidemiological data support that an increased uptake of spermidine as a caloric restriction mimic can reduce overall mortality associated with cancers. The possible mechanisms between spermidine and cancer development may be related to the precise regulation of polyamine metabolism, anti-cancer immunosurveillance, autophagy, and apoptosis. Increased intake of polyamine seems to suppress tumorigenesis, but appears to accelerate the growth of established tumors. Based on these observations and the absolute requirement for polyamines in tumor growth, spermidine could be a rational target for chemoprevention and clinical therapeutics of cancers.
亚精胺作为多胺成员中的一种天然成分，最初从精液中分离出来，也存在于许多天然植物中，能够负责真核生物的细胞生长和发育。亚精胺的补充可以延长多种物种的健康和寿命。尽管多胺水平的升高和多胺代谢限速酶的调节已被确定为许多癌症的生物标志物，但最近的流行病学数据支持，作为热量限制模拟物的亚精胺摄取增加可以降低与癌症相关的总死亡率。亚精胺与癌症发展之间的可能机制可能与多胺代谢的精确调节、抗癌免疫监视、自噬和细胞凋亡有关。多胺的摄入增加似乎抑制了肿瘤发生，但似乎加速了已建立的肿瘤的生长。基于这些观察结果和肿瘤生长对多胺的绝对需求，亚精胺可能是癌症化学预防和临床治疗的合理靶点。
