Division of Pulmonary and Critical Care Medicine, Department of Medicine, Boston University, Boston, MA.
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Boston University, Boston, MA.
Am J Infect Control. 2020 Aug;48(8):883-889. doi: 10.1016/j.ajic.2020.05.024. Epub 2020 May 25.
The past 4 months, the emergence and spread of novel 2019 SARS-Cov-2 (COVID-19) has led to a global pandemic which is rapidly depleting supplies of personal protective equipment worldwide. There are currently over 1.6 million confirmed cases of COVID-19 worldwide which has resulted in more the 100,000 deaths. As these numbers grow daily, hospitals are being forced to reuse surgical masks in hopes of conserving their dwindling supply. Since COVID-19 will most likely have effects that last for many months, our nationwide shortage of masks poses a long term issue that must be addressed immediately.
Based on a previous study by Quan et al., a salt-based soaking strategy has been reported to enhance the filtration ability of surgical masks. We propose a similar soaking process which uses materials widely available in anyone's household. We tested this method of pretreating a variety of materials with a salt-based solution by a droplet test using fluorescently stained nanoparticles similar in size to the COVID-19 virus.
In this study, we found that paper towels and surgical masks pretreated with the salt-based solution showed a noticeable increase in filtration of nanoparticles similar in size to the COVID-19 virus. We also show that the TWEEN20 used by Quan et al. is not a critical component for the solution, and using salt alone in solution still provides a dramatically increased level of protection.
We believe this method will allow for healthcare workers to create a disposable added layer of protection to their surgical masks, N95s, or homemade masks by using household available products. Adoption of this method may play an essential role in ensuring the safety of healthcare workers during the COVID-19 pandemic and any pandemics that may arise in the future.
过去 4 个月,新型 2019 年 SARS-CoV-2(COVID-19)的出现和传播导致了一场全球大流行,全球个人防护设备的供应迅速枯竭。目前全球有超过 160 万例 COVID-19 确诊病例,导致超过 10 万人死亡。随着这些数字每天都在增加,医院被迫重复使用外科口罩,以希望节省日益减少的供应。由于 COVID-19 很可能会持续数月,因此我国口罩短缺是一个必须立即解决的长期问题。
基于 Quan 等人的先前研究,已经报道了一种基于盐的浸泡策略来增强外科口罩的过滤能力。我们提出了一种类似的浸泡过程,该过程使用每个人家中都广泛可用的材料。我们通过使用与 COVID-19 病毒大小相似的荧光染色纳米颗粒进行液滴测试,测试了用基于盐的溶液预处理各种材料的这种方法。
在这项研究中,我们发现用基于盐的溶液预处理的纸巾和外科口罩对大小相似的纳米颗粒的过滤能力明显提高。我们还表明,Quan 等人使用的 TWEEN20 不是溶液的关键成分,并且单独使用盐溶液仍能提供显著增强的保护水平。
我们相信,这种方法将使医护人员能够通过使用家庭中可用的产品为外科口罩、N95 口罩或自制口罩创造一次性的附加保护层。在 COVID-19 大流行和未来可能出现的任何大流行期间,采用这种方法可能对确保医护人员的安全发挥重要作用。