Centre for Tropical Crops and Biocommodities, Queensland University of Technology, Brisbane, QLD 4000, Australia.
Department of Plant Pathology, University of Wisconsin-, Madison, WI 53706, USA.
Trends Plant Sci. 2020 Nov;25(11):1131-1140. doi: 10.1016/j.tplants.2020.04.012. Epub 2020 May 25.
Programmed cell death (PCD) is a genetically regulated process for the selective demise of unwanted and damaged cells. Although our understanding of plant PCD pathways has advanced significantly, doubts remain on the extent of conservation of animal apoptosis in plants. At least at the primary sequence level, plants do not encode the regulators of animal apoptosis. Structural analyses have enabled the identification of the B cell lymphoma 2 (Bcl-2)-associated athanogene (BAG) family of co-chaperones in plants. This discovery suggests that some aspects of animal PCD are conserved in plants, while the varied subcellular localization of plant BAGs indicates that they may have evolved distinct functions. Here we review plant BAG proteins, with an emphasis on their roles in the regulation of plant PCD.
程序性细胞死亡 (PCD) 是一种基因调控的过程，用于选择性地清除不需要的和受损的细胞。尽管我们对植物 PCD 途径的理解有了显著的进展，但对于动物凋亡在植物中的保守程度仍存在疑问。至少在初级序列水平上，植物不编码动物凋亡的调节剂。结构分析使我们能够鉴定植物中的 B 细胞淋巴瘤 2 (Bcl-2) 相关抗凋亡基因 (BAG) 家族的共伴侣。这一发现表明，动物 PCD 的某些方面在植物中是保守的，而植物 BAG 的不同亚细胞定位表明它们可能已经进化出不同的功能。在这里，我们综述了植物 BAG 蛋白，重点介绍它们在植物 PCD 调控中的作用。
