• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

可变剪接事件在头颈部鳞状细胞癌中的预后作用

Prognostic role of alternative splicing events in head and neck squamous cell carcinoma.

作者信息

Ding Yanni, Feng Guang, Yang Min

机构信息

Department of Breast Surgery, Shaan Xi Provincial Tumor Hospital, Xi'an City, Shaan Xi Province 710000 China.

2The Third Department of Burns and Plastic Surgery and Center of Wound Repair, The Fourth Medical Center of PLA General Hospital, Beijing, 100048 China.

出版信息

Cancer Cell Int. 2020 May 14;20:168. doi: 10.1186/s12935-020-01249-0. eCollection 2020.

DOI:10.1186/s12935-020-01249-0
PMID:32467664
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7227031/
Abstract

BACKGROUND

Aberrant alternative splicing (AS) is implicated in biological processes of cancer. This study aims to reveal prognostic AS events and signatures that may serve as prognostic predictors for head and neck squamous cell carcinoma (HNSCC).

METHODS

Prognostic AS events in HNSCC were identified by univariate COX analysis. Prognostic signatures comprising prognostic AS events were constructed for prognosis prediction in patients with HNSCC. The correlation between the percent spliced in (PSI) values of AS events and the expression of splicing factors (SFs) was analyzed by Pearson correlation analysis. Gene functional annotation analysis was performed to reveal pathways in which prognostic AS is enriched.

RESULTS

A total of 27,611 AS events in 15,873 genes were observed, and there were 3433 AS events in 2624 genes significantly associated with overall survival (OS) for HNSCC. Moreover, we found that AS prognostic signatures could accurately predict HNSCC prognosis. SF-AS regulatory networks were constructed according to the correlation between PSI values of AS events and the expression levels of SFs.

CONCLUSIONS

Our study identified prognostic AS events and signatures. Furthermore, it established SF-AS networks in HNSCC that were valuable in predicting the prognosis of patients with HNSCC and elucidating the regulatory mechanisms underlying AS in HNSCC.

摘要

背景

异常可变剪接（AS）与癌症的生物学过程有关。本研究旨在揭示可能作为头颈部鳞状细胞癌（HNSCC）预后预测指标的预后性AS事件和特征。

方法

通过单因素COX分析确定HNSCC中的预后性AS事件。构建包含预后性AS事件的预后特征，用于预测HNSCC患者的预后。通过Pearson相关分析分析AS事件的剪接百分率（PSI）值与剪接因子（SFs）表达之间的相关性。进行基因功能注释分析以揭示预后性AS富集的途径。

结果

共观察到15873个基因中的27611个AS事件，其中2624个基因中的3433个AS事件与HNSCC的总生存期（OS）显著相关。此外，我们发现AS预后特征可以准确预测HNSCC的预后。根据AS事件的PSI值与SFs表达水平之间的相关性构建了SF-AS调控网络。

结论

我们的研究确定了预后性AS事件和特征。此外，它在HNSCC中建立了SF-AS网络，这对于预测HNSCC患者的预后以及阐明HNSCC中AS的调控机制具有重要价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdf4/7227031/7835af132eb6/12935_2020_1249_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdf4/7227031/8bb0425b8a04/12935_2020_1249_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdf4/7227031/f905ba2b8b0d/12935_2020_1249_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdf4/7227031/2b99c63e1819/12935_2020_1249_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdf4/7227031/718a2bc60594/12935_2020_1249_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdf4/7227031/f0cb9582815f/12935_2020_1249_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdf4/7227031/039f536add2f/12935_2020_1249_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdf4/7227031/7835af132eb6/12935_2020_1249_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdf4/7227031/8bb0425b8a04/12935_2020_1249_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdf4/7227031/f905ba2b8b0d/12935_2020_1249_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdf4/7227031/2b99c63e1819/12935_2020_1249_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdf4/7227031/718a2bc60594/12935_2020_1249_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdf4/7227031/f0cb9582815f/12935_2020_1249_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdf4/7227031/039f536add2f/12935_2020_1249_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdf4/7227031/7835af132eb6/12935_2020_1249_Fig7_HTML.jpg

相似文献

1
Prognostic role of alternative splicing events in head and neck squamous cell carcinoma.可变剪接事件在头颈部鳞状细胞癌中的预后作用
Cancer Cell Int. 2020 May 14;20:168. doi: 10.1186/s12935-020-01249-0. eCollection 2020.
2
Survival-Associated Alternative Splicing Events and Prognostic Signatures in Pancreatic Cancer.胰腺癌中与生存相关的可变剪接事件及预后特征
Front Genet. 2020 Sep 30;11:522383. doi: 10.3389/fgene.2020.522383. eCollection 2020.
3
Characterization of alternative splicing events and prognostic signatures in breast cancer.乳腺癌中可变剪接事件和预后特征的分析。
BMC Cancer. 2021 May 22;21(1):587. doi: 10.1186/s12885-021-08305-6.
4
Systematic Profile Analysis of Prognostic Alternative Messenger RNA Splicing Signatures and Splicing Factors in Head and Neck Squamous Cell Carcinoma.头颈部鳞状细胞癌中预后替代信使 RNA 剪接特征和剪接因子的系统谱分析。
DNA Cell Biol. 2019 Jul;38(7):627-638. doi: 10.1089/dna.2019.4644. Epub 2019 Apr 26.
5
Identification of a prognostic alternative splicing signature in oral squamous cell carcinoma.口腔鳞状细胞癌中预后性可变剪接标志的鉴定。
J Cell Physiol. 2020 May;235(5):4804-4813. doi: 10.1002/jcp.29357. Epub 2019 Oct 21.
6
Novel Insights Into Triple-Negative Breast Cancer Prognosis by Comprehensive Characterization of Aberrant Alternative Splicing.通过异常可变剪接的综合表征对三阴性乳腺癌预后的新见解
Front Genet. 2020 Jun 11;11:534. doi: 10.3389/fgene.2020.00534. eCollection 2020.
7
Survival-Associated Alternative Messenger RNA Splicing Signatures in Pancreatic Ductal Adenocarcinoma: A Study Based on RNA-Sequencing Data.胰腺导管腺癌中与生存相关的可变剪接信使 RNA 特征：基于 RNA 测序数据的研究。
DNA Cell Biol. 2019 Nov;38(11):1207-1222. doi: 10.1089/dna.2019.4862. Epub 2019 Sep 4.
8
Development and validation of a novel survival model for head and neck squamous cell carcinoma based on autophagy-related genes.基于自噬相关基因的头颈部鳞状细胞癌新型生存模型的建立和验证。
Genomics. 2021 Jan;113(1 Pt 2):1166-1175. doi: 10.1016/j.ygeno.2020.11.017. Epub 2020 Nov 20.
9
Identification of Survival-Associated Alternative Splicing Signatures in Lung Squamous Cell Carcinoma.肺鳞状细胞癌中生存相关可变剪接特征的鉴定
Front Oncol. 2020 Sep 30;10:587343. doi: 10.3389/fonc.2020.587343. eCollection 2020.
10
Identification and validation of an alternative splicing-based prognostic signature for head and neck squamous cell carcinoma.头颈部鳞状细胞癌基于可变剪接的预后标志物的鉴定与验证
J Cancer. 2020 May 18;11(15):4571-4580. doi: 10.7150/jca.44746. eCollection 2020.

引用本文的文献

1
Alternative Splicing Landscape of Head and Neck Squamous Cell Carcinoma.头颈部鳞状细胞癌的可变剪接图谱
Technol Cancer Res Treat. 2024 Jan-Dec;23:15330338241272051. doi: 10.1177/15330338241272051.
2
Splicing Machinery Is Impaired in Oral Squamous Cell Carcinomas and Linked to Key Pathophysiological Features.剪接 machinery 是在口腔鳞状细胞 carcinoma 中受损，并与关键的病理生理特征有关。
Int J Mol Sci. 2024 Jun 25;25(13):6929. doi: 10.3390/ijms25136929.
3
IQGAP1 and RNA Splicing in the Context of Head and Neck via Phosphoproteomics.

本文引用的文献

1
Systemic Analysis of RNA Alternative Splicing Signals Related to the Prognosis for Head and Neck Squamous Cell Carcinoma.与头颈部鳞状细胞癌预后相关的RNA可变剪接信号的系统分析
Front Oncol. 2020 Feb 7;10:87. doi: 10.3389/fonc.2020.00087. eCollection 2020.
2
Identification of a Novel RBPMS-ROS1 Fusion in an Adolescent Patient With Microsatellite-instable Advanced Lung Adenocarcinoma Sensitive to Crizotinib: A Case Report.一名对克唑替尼敏感的微卫星不稳定晚期肺腺癌青少年患者中新型RBPMS-ROS1融合的鉴定：病例报告
Clin Lung Cancer. 2020 Mar;21(2):e78-e83. doi: 10.1016/j.cllc.2019.09.003. Epub 2019 Sep 26.
3
A novel splice variant of LOXL2 promotes progression of human papillomavirus-negative head and neck squamous cell carcinoma.
IQGAP1 和头颈部通过磷酸化蛋白质组学调控的 RNA 剪接。
J Proteome Res. 2022 Sep 2;21(9):2211-2223. doi: 10.1021/acs.jproteome.2c00309. Epub 2022 Aug 18.
4
Temporal Modulation of Differential Alternative Splicing in HaCaT Human Keratinocyte Cell Line Chronically Exposed to Arsenic for up to 28 Wk.砷暴露长达 28 周对 HaCaT 人角质形成细胞系中差异剪接的时间调节。
Environ Health Perspect. 2022 Jan;130(1):17011. doi: 10.1289/EHP9676. Epub 2022 Jan 24.
5
Comprehensive Analysis of Splicing Factor and Alternative Splicing Event to Construct Subtype-Specific Prognosis-Predicting Models for Breast Cancer.用于构建乳腺癌亚型特异性预后预测模型的剪接因子和可变剪接事件的综合分析
Front Genet. 2021 Sep 24;12:736423. doi: 10.3389/fgene.2021.736423. eCollection 2021.
LOXL2 的一种新型剪接变体促进了人乳头瘤病毒阴性头颈部鳞状细胞癌的进展。
Cancer. 2020 Feb 15;126(4):737-748. doi: 10.1002/cncr.32610. Epub 2019 Nov 13.
4
Comprehensive characterization of the alternative splicing landscape in head and neck squamous cell carcinoma reveals novel events associated with tumorigenesis and the immune microenvironment.全面描绘头颈部鳞状细胞癌中的可变剪接全景，揭示与肿瘤发生和免疫微环境相关的新事件。
Theranostics. 2019 Oct 14;9(25):7648-7665. doi: 10.7150/thno.36585. eCollection 2019.
5
Transcripto-based network analysis reveals a model of gene activation in tongue squamous cell carcinomas.基于转录组的网络分析揭示了舌鳞状细胞癌的基因激活模型。
Head Neck. 2019 Dec;41(12):4098-4110. doi: 10.1002/hed.25952. Epub 2019 Oct 7.
6
Determining the prognostic significance of alternative splicing events in soft tissue sarcoma using data from The Cancer Genome Atlas.利用癌症基因组图谱数据确定软组织肉瘤中可变剪接事件的预后意义。
J Transl Med. 2019 Aug 23;17(1):283. doi: 10.1186/s12967-019-2029-6.
7
Statistical predictions with glmnet.使用 glmnet 进行统计预测。
Clin Epigenetics. 2019 Aug 23;11(1):123. doi: 10.1186/s13148-019-0730-1.
8
Pan-cancer analysis of clinical relevance of alternative splicing events in 31 human cancers.泛癌症分析 31 种人类癌症中剪接事件的临床相关性。
Oncogene. 2019 Oct;38(40):6678-6695. doi: 10.1038/s41388-019-0910-7. Epub 2019 Aug 7.
9
Alternative splicing events are prognostic in hepatocellular carcinoma.可变剪接事件在肝细胞癌中具有预后价值。
Aging (Albany NY). 2019 Jul 13;11(13):4720-4735. doi: 10.18632/aging.102085.
10
Novel prognostic clinical factors and biomarkers for outcome prediction in head and neck cancer: a systematic review.头颈部癌症预后的新型临床因素和生物标志物：系统评价。
Lancet Oncol. 2019 Jun;20(6):e313-e326. doi: 10.1016/S1470-2045(19)30177-9.