一株轮状病毒 A 田间分离株的基因型组合，在接种轮状病毒疫苗的奶牛群中出现了一种不常见的 G8P[11]基因型组合。
Genotype constellation of a rotavirus A field strain with an uncommon G8P[11] genotype combination in a rotavirus-vaccinated dairy cattle herd.
机构信息
Laboratory of Animal Virology, Department of Veterinary Preventive Medicine, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid-Campus Universitário, PO Box 10011, Londrina, Paraná, 86057-970, Brazil.
Post Graduate Program in Animal Health and Production, Universidade Pitágoras Unopar, Arapongas, Paraná, Brazil.
出版信息
Arch Virol. 2020 Aug;165(8):1855-1861. doi: 10.1007/s00705-020-04675-7. Epub 2020 May 29.
In this report we describe the genotype constellation of a bovine rotavirus A (RVA) strain with an uncommon G8P[11] genotype combination. The RVA/Cow-wt/BRA/Y136/2017/G8P[11] strain was classified as G8-P[11]-I2-R5-C2-M2-A3-N2-T9-E2-H3. Phylogenetic analysis based on the VP7 gene showed that the Y136 strain and a human G8P[1] strain comprise a putative new (VII) lineage for the G8 genotype. In addition, two other genotypes, R5 (VP1) and T9 (NSP3), were identified in the constellation of Y136 that are rarely found in RVA strains of bovine origin. The immunological pressure caused by regular vaccination of cows might be responsible for the selection of heterologous RVA strains.
在本报告中，我们描述了一株具有罕见 G8P[11] 基因型组合的牛轮状病毒 A（RVA）株的基因型组合。RVA/Cow-wt/BRA/Y136/2017/G8P[11] 株被分类为 G8-P[11]-I2-R5-C2-M2-A3-N2-T9-E2-H3。基于 VP7 基因的系统进化分析表明，Y136 株和一株人源 G8P[1] 株构成了 G8 基因型的一个假定新（VII）谱系。此外，在 Y136 的基因型组合中还鉴定出了另外两种基因型，即 R5（VP1）和 T9（NSP3），它们在牛源 RVA 株中很少见。牛的常规疫苗接种所带来的免疫压力可能导致了异源 RVA 株的选择。
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