Centre of Tropical Medicine and Travel Medicine, Department of Infectious Diseases, Amsterdam University Medical Centres, Amsterdam Public Health, Amsterdam Infection & Immunity, Amsterdam, the Netherlands; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany.
Centre of Tropical Medicine and Travel Medicine, Department of Infectious Diseases, Amsterdam University Medical Centres, Amsterdam Public Health, Amsterdam Infection & Immunity, Amsterdam, the Netherlands.
Travel Med Infect Dis. 2020 Nov-Dec;38:101753. doi: 10.1016/j.tmaid.2020.101753. Epub 2020 May 27.
It has been well documented that Zika virus (ZIKV) can be sexually transmitted. Dengue virus (DENV) shows many similarities with ZIKV; both belong to the genus Flavivirus and share the same main vector route of transmission. Moreover, they share overall architectural features on a molecular level, with a highly similar structure and distinctive insertions, deletions and mutations of their respective E proteins, and it has been suggested that they use a common pathophysiological pathway. In view of similarities with other sexually transmissible viruses, the question arises as to whether DENV could also be sexually transmissible. Limited animal model data do not suggest otherwise. The presence of dengue virus in - and human-to-human, non-vector transmission from - various bodily fluids other than semen or vaginal secretions has been documented anecdotally. Several anecdotal reports described prolonged presence of DENV in semen, urine and vaginal secretions. In 2019, two cases of likely sexual transmission were reported from Spain and South Korea, respectively. We discuss the evidence for and against a relevant DENV sexual transmission potential, highlight controversies and propose a future research agenda on this issue.
已有充分文献记载表明寨卡病毒（ZIKV）可通过性传播。登革热病毒（DENV）与 ZIKV 有许多相似之处；两者均属于黄病毒属，具有相同的主要传播途径。此外，它们在分子水平上具有整体结构特征，E 蛋白结构高度相似，且具有独特的插入、缺失和突变，据推测它们使用共同的病理生理途径。鉴于与其他性传播病毒的相似性，人们不禁会问 DENV 是否也可通过性传播。有限的动物模型数据并未表明不会如此。有文献记载，除精液或阴道分泌物外，登革热病毒存在于各种体液中，并可在人与人之间非媒介传播。有几则病例报告描述了 DENV 在精液、尿液和阴道分泌物中的长时间存在。2019 年，分别有两例来自西班牙和韩国的可能性传播病例报告。我们讨论了 DENV 具有性传播潜力的相关证据，突出了争议，并就该问题提出了未来的研究议程。
