Department of Community Healthcare and Geriatrics, Nagoya University Graduate School of Medicine, Aichi, Japan.
Department of Cardiovascular, Respiratory, Nephrological, Anesthesiologic, and Geriatric Sciences, Policlinico Umberto I, "La Sapienza" University of Rome, Rome, Italy.
J Alzheimers Dis. 2020;76(1):435-442. doi: 10.3233/JAD-200169.
Cognitive impairment is linked to decreased quality of life (QOL), but few studies have investigated the impact of comorbid sarcopenia.
The aim of this study was to elucidate the association of sarcopenia with QOL in patients with early dementia and mild cognitive impairment.
Individuals with a Clinical Dementia Rating of 0.5 or 1 and a Mini-Mental State Examination score of 20-30 underwent a battery of neuropsychological assessments administered by a group of well-trained clinical psychologists. The EQ-5D was completed by both the patients and their main caregivers. EQ-5D utility and visual analog scale scores were measured. Sarcopenia was defined according to the criteria published in the 2019 consensus update by the Asian Working Group for Sarcopenia.
Patients with sarcopenia had significantly lower scores on the Digit Symbol Substitution Test and Trail Making Test Part A. There was a significant negative association between sarcopenia and both self- and proxy-rated EQ-5D utility scores independent of potential confounding factors. However, there was no association between QOL visual analog scale scores and sarcopenia.
Given that sarcopenia is often found in individuals with cognitive impairment, early detection by timely screening and effective intervention may help to maintain or improve QOL in this population. However, this study could not determine whether reduced QOL is a direct consequence of sarcopenia.
认知障碍与生活质量（QOL）下降有关，但很少有研究探讨合并肌少症的影响。
本研究旨在阐明肌少症与早期痴呆和轻度认知障碍患者 QOL 的关系。
临床痴呆评定量表（CDR）评分为 0.5 或 1，简易精神状态检查量表（MMSE）评分为 20-30 的个体接受了一组经过良好训练的临床心理学家进行的神经心理评估。EQ-5D 由患者及其主要照顾者共同完成。测量 EQ-5D 效用和视觉模拟量表评分。肌少症根据 2019 年亚洲肌少症工作组共识更新版发布的标准定义。
患有肌少症的患者在数字符号替代测试和连线测试 A 部分的得分明显较低。在考虑到潜在混杂因素后，肌少症与自我和代理评估的 EQ-5D 效用评分之间存在显著的负相关。然而，QOL 视觉模拟量表评分与肌少症之间没有关联。
鉴于认知障碍患者中常发现肌少症，通过及时筛查和有效干预进行早期检测可能有助于维持或改善该人群的 QOL。然而，本研究无法确定 QOL 下降是否是肌少症的直接后果。
