CIAFEL, Centro de Investigação em Atividade Física, Saúde e Lazer, Universidade do Porto, Porto, Portugal.
Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal.
Qual Life Res. 2021 Aug;30(8):2255-2264. doi: 10.1007/s11136-021-02828-y. Epub 2021 Mar 28.
This study aimed to identify the association between health-related physical indicators-sarcopenia-related factors, physical fitness, independence in activities of daily living (ADL) and habitual physical activity-and self-rated quality of life (QoL) in people with neurocognitive disorder (NCD).
This cross-sectional study included 115 participants (78.22 ± 7.48 years; 74.8% female) clinically diagnosed with NCD. Self-rated QoL was evaluated using The Quality of Life-Alzheimer's Disease (QoL-AD). Dual energy X-ray Absorptiometry, handgrip strength, Short Physical Performance Battery, and the 6-m Walk test were used to assess sarcopenia-related factors. Senior Fitness Test and One Leg Balance test, Barthel Index, Baecke Modified Habitual Physical Activity Questionnaire were used to determine physical fitness, independence in ADL and physical activity, respectively. Regressions analyses were performed to examine associations between these variables and QoL-AD.
Data from univariable linear regression analysis revealed that self-rated QoL was associated with sarcopenia-related factors (lower body function, handgrip strength, gait speed, and appendicular skeletal muscle mass index-ASMI), physical fitness (upper-and-lower-body strength, agility/dynamic balance, cardiorespiratory fitness and body mass index), habitual physical activity and independence in ADL. Results from multivariable regression analysis showed that ASMI (B = 1.846, 95% CI 0.165-3.527, p = 0.032) and lower body function (B = 0.756, 95% CI 0.269-1.242, p = 0.003) were positively associated with self-rated QoL. These variables explained 20.1% of the variability seen in self-rated QoL, controlling for age, sex, marital status and education.
Sarcopenia-related factors, namely lower body function and ASMI, should be acknowledged in future research studies as critical health-related indicators associated with QoL in people with NCD.
ClinicalTrials.gov-identifier number NCT04095962.
本研究旨在确定与健康相关的生理指标（与肌少症相关的因素、身体机能、日常生活活动（ADL）独立性和习惯性体力活动）与神经认知障碍（NCD）患者的自我报告生活质量（QoL）之间的关联。
本横断面研究纳入了 115 名临床诊断为 NCD 的患者（78.22±7.48 岁；74.8%为女性）。使用生活质量-阿尔茨海默病问卷（QoL-AD）评估自我报告的 QoL。使用双能 X 射线吸收法、握力、简易体能测试、6 米步行测试评估与肌少症相关的因素。使用高级体能测试和单腿平衡测试、巴氏指数、贝克习惯性体力活动问卷分别评估身体机能、ADL 独立性和体力活动。进行回归分析以检验这些变量与 QoL-AD 之间的关联。
单变量线性回归分析数据显示，自我报告的 QoL 与与肌少症相关的因素（下半身功能、握力、步速和四肢骨骼肌质量指数-ASMI）、身体机能（上下肢力量、敏捷/动态平衡、心肺功能和身体质量指数）、习惯性体力活动和 ADL 独立性相关。多变量回归分析结果显示，ASMI（B=1.846，95%CI 0.165-3.527，p=0.032）和下半身功能（B=0.756，95%CI 0.269-1.242，p=0.003）与自我报告的 QoL 呈正相关。在校正年龄、性别、婚姻状况和教育程度后，这些变量可以解释自我报告 QoL 变异性的 20.1%。
与肌少症相关的因素，即下半身功能和 ASMI，应在未来的研究中被视为与 NCD 患者 QoL 相关的关键健康相关指标。
ClinicalTrials.gov 标识符号 NCT04095962。
