Noort W A, de Zwart F A, Keirse M J
Department of Obstetrics and Gynecology, Leiden University Hospital, the Netherlands.
Prostaglandins. 1988 Apr;35(4):573-82. doi: 10.1016/0090-6980(88)90032-9.
Urinary excretion of 6-keto-PGF1 alpha was measured by high pressure liquid chromatography and radioimmunoassay at various stages of pregnancy and labor. In the first trimester of pregnancy, urinary 6-keto-PGF1 alpha concentrations were not different from those measured before pregnancy, but they showed a significant increase in the second trimester of pregnancy (p less than 0.001). The levels rose further in the third trimester, although this increase was not statistically significant when compared to levels obtained in the second trimester. There was no evidence for a significant change in 6-keto-PGF1 alpha excretion with the onset of labor. During well-established, progressive labor mean values of 6-keto-PGF1 alpha excretion were about twice as high as before the onset of labor, but the range of values during labor was so wide that there was no statistical difference with values obtained in the second half of pregnancy. It is concluded that the increase in the urinary excretion of 6-keto-PGF1 alpha occurs later in pregnancy than the increase in TXB2 excretion and that labor at term is not associated with marked changes in 6-keto-PGF1 alpha excretion.
在妊娠和分娩的各个阶段，通过高压液相色谱法和放射免疫分析法测定了6-酮-前列环素F1α的尿排泄量。在妊娠早期，尿中6-酮-前列环素F1α的浓度与妊娠前测得的浓度无差异，但在妊娠中期显著升高（p<0.001）。在妊娠晚期水平进一步升高，尽管与妊娠中期获得的水平相比，这种升高无统计学意义。没有证据表明随着分娩开始，6-酮-前列环素F1α的排泄有显著变化。在确立良好、进展性的分娩过程中，6-酮-前列环素F1α排泄的平均值约为分娩开始前的两倍，但分娩期间的值范围很广，与妊娠后半期获得的值无统计学差异。得出的结论是，6-酮-前列环素F1α尿排泄量的增加发生在妊娠后期，晚于血栓素B2排泄量的增加，并且足月分娩与6-酮-前列环素F1α排泄的明显变化无关。
