Mortensen P B, Kristensen S D, Bloch A, Jacobsen B A, Rasmussen S N
Dept. of Surgical Gastroenterology, Aalborg Hospital, Denmark.
Scand J Gastroenterol. 1988 Nov;23(9):1085-8. doi: 10.3109/00365528809090173.
In a prospective study abdominal paracentesis with ascitic fluid aspiration was performed in 54 consecutive patients with ascites of unknown cause. The ascitic fluid was examined cytologically and bacteriologically. The total cholesterol concentration was measured with an enzymatic colorimetric method. Malignant disease was diagnosed in 34 patients. Two of them had both malignant disease and liver cirrhosis and were excluded. Seventeen patients had liver cirrhosis, one had acute pancreatitis, and two had decompensated heart disease. The diagnostic value of an ascitic cholesterol concentration greater than 1.2 mmol/l in terms of predicting malignant disease was 87.5% (95% confidence limits, 71.0-96.5). The predictive value of an ascitic cholesterol concentration less than or equal to 1.2 mmol/l in terms of benign disease was 80.0% (95% confidence limits, 56.3-94.3). It is concluded that ascitic cholesterol measurement is a valuable supplement to cytologic examination in distinguishing between ascites of malignant and benign origin.
在一项前瞻性研究中，对54例连续的不明原因腹水患者进行了腹腔穿刺放腹水操作。对腹水进行了细胞学和细菌学检查。采用酶比色法测定总胆固醇浓度。34例患者被诊断为恶性疾病。其中2例同时患有恶性疾病和肝硬化，被排除在外。17例患者患有肝硬化，1例患有急性胰腺炎，2例患有失代偿性心脏病。腹水胆固醇浓度大于1.2 mmol/l对预测恶性疾病的诊断价值为87.5%（95%置信区间，71.0 - 96.5）。腹水胆固醇浓度小于或等于1.2 mmol/l对良性疾病的预测价值为80.0%（95%置信区间，56.3 - 94.3）。结论是，腹水胆固醇测定是区分恶性和良性腹水来源的细胞学检查的有价值补充。
