Korochkin I M, Kartelishev A V, Leshakov S Iu, Kapustina G M, Vernekina N S
Ter Arkh. 1988;60(12):40-4.
The paper is devoted to analysis of clinico-biochemical indices and a quest for additional pathologico-chemical criteria at the cell membrane level of the efficacy of helium-neon laser therapy in coronary heart disease (CHD). Another task was to decipher a number of metabolic signs of the phenomenon of CHD "exacerbation" in laser therapy (during 4-6 sessions). Positive clinical results were obtained in 98% of the patients. A favorable time course was noted in serum lipoprotein spectrum indices and in lipid and phospholipid structure of erythrocyte membranes. Laser therapy caused mobilization of the cell membrane antioxidant defense. The 4th-6th session of irradiation was marked by temporary clinical deterioration--"exacerbation" of disease accompanied by an increase in the level of erythrocyte total phospholipids (at the expense of PTEA), a decrease in free fatty acid deficiency against a background of advancing alpha-tocopherol deficiency and a rise of the blood level of lipid peroxidation primary products (diene conjugates). A conclusion was that membrane protective drugs and drugs enhancing cell energy and antioxidant defense resources promoting the "deactivation" of influence on the membrane of lipid peroxidation metabolites (tocopherol, Essentiale, retinol, etc.) should be incorporated in therapy of CHD in order to prevent the phenomenon of its "exacerbation".
本文致力于分析临床生化指标，并探寻在冠心病（CHD）氦氖激光治疗疗效的细胞膜水平上的额外病理化学标准。另一项任务是解读激光治疗（4 - 6个疗程期间）冠心病“恶化”现象的一些代谢迹象。98%的患者获得了积极的临床结果。血清脂蛋白谱指标以及红细胞膜的脂质和磷脂结构呈现出良好的时间进程。激光治疗引发了细胞膜抗氧化防御的动员。第4 - 6次照射的特点是出现暂时的临床恶化——疾病“恶化”，伴有红细胞总磷脂水平升高（以PTEA为代价），在α - 生育酚缺乏加剧的背景下游离脂肪酸缺乏减少，以及脂质过氧化初级产物（二烯共轭物）血水平升高。得出的结论是，在冠心病治疗中应加入膜保护药物以及增强细胞能量和抗氧化防御资源的药物，以促进脂质过氧化代谢产物（生育酚、易善力、视黄醇等）对膜影响的“失活”，从而预防其“恶化”现象。
