Verdina Tommaso, Piaggi Stefania, Peschiera Riccardo, Russolillo Valeria, Ferraro Vanessa, Chester Johanna, Mastropasqua Rodolfo, Cavallini Gian Maria
Institute of Ophthalmology, University of Modena and Reggio Emilia , Modena, Italy.
Department of Dermatology, University of Modena and Reggio Emilia , Modena, Italy.
Semin Ophthalmol. 2020 Apr 2;35(3):164-169. doi: 10.1080/08820538.2020.1774624. Epub 2020 Jun 1.
To evaluate the effectiveness of Visual Evoked Potential (VEP) biofeedback rehabilitation in selected low vision patients with advanced age-related macular degeneration (AMD).
Retrospective observational cohort study.
Patients affected by advanced AMD, central macular atrophy with unstable fixation and best corrected visual acuity (BCVA) between 20/100 and 20/320 were considered. Selected patients underwent fundus photography and microperimetry with fixation analysis for the selected eye (highest BCVA). Ten consecutive training sessions of 10 min each were performed twice a week in the selected eye with Retimax Vision Trainer (CSO, Florence). BCVA, reading acuity and reading speed, contrast sensitivity, fixation, retinal sensitivity and quality of life questionnaire (VFQ-25) were evaluated at baseline and 7 days following the final session.
Significant improvements in terms of BCVA [ = .011], reading speed [ = .007], VFQ-25 score [ = .007], retinal sensitivity [ = .021] and fixation stability in the central 2° and 4° [ = .048; = .037] post-treatment were observed for the 9 patients enrolled, with insignificant improvements observed in reading acuity and contrast sensitivity [ = .335; = .291].
Preliminary results support VEP biofeedback rehabilitation improvements for visual function and quality of life in advanced AMD patients with low vision.
评估视觉诱发电位（VEP）生物反馈康复对选定的患有晚期年龄相关性黄斑变性（AMD）的低视力患者的有效性。
回顾性观察队列研究。
纳入受晚期AMD影响、中心黄斑萎缩且注视不稳定、最佳矫正视力（BCVA）在20/100至20/320之间的患者。对选定的患者（视力最好的眼睛）进行眼底照相和微视野检查并进行注视分析。使用Retimax视觉训练仪（CSO，佛罗伦萨）对选定的眼睛每周进行两次，每次10分钟，连续进行10次训练。在基线和最后一次训练后7天评估BCVA、阅读视力和阅读速度、对比敏感度、注视、视网膜敏感度和生活质量问卷（VFQ - 25）。
在纳入的9名患者中，观察到治疗后BCVA[P = 0.011]、阅读速度[P = 0.007]、VFQ - 25评分[P = 0.007]、视网膜敏感度[P = 0.021]以及中心2°和4°的注视稳定性[P = 0.048；P = 0.037]有显著改善，而阅读视力和对比敏感度改善不显著[P = 0.335；P = 0.291]。
初步结果支持VEP生物反馈康复可改善晚期AMD低视力患者的视觉功能和生活质量。
