Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, 100 Haining Road, Hongkou District, Shanghai, 200080, China.
National Clinical Research Center for Eye Diseases, Shanghai, 200080, China.
BMC Ophthalmol. 2022 Apr 28;22(1):197. doi: 10.1186/s12886-022-02419-6.
To evaluate the efficacy of MP-3 microperimeter biofeedback fixation training (MBFT) in vision rehabilitation of low-vision patients affected by macular disease with central vision loss.
Seventeen eyes (7 age-related macular degeneration, 10 myopic maculopathy) of 17 patients were included in this prospective, interventional study. The preferred retinal locus was determined by comprehensive ophthalmoscopic fundus evaluation including fundus photography, autofluorescence, optical coherence tomography, and microperimetry. The rehabilitation consisted of three 10-min sessions per eye to be performed twice per week for 20 consecutive weeks using the MP-3 microperimeter. Best corrected visual acuity (BCVA), reading speed, mean central sensitivity, the percentages of fixation points within specified regions, bivariate contour ellipse area (BCEA) and the 25-item National Eye Institute visual function questionnaire (NEI-VFQ-25) were recorded pre- and post-training.
The final BCVA, reading speed and mean central sensitivity all showed significant improvements after rehabilitation (P < 0.0001, P = 0.0013, and P = 0.0002, respectively). The percentages of fixation points located within 2° and 4° diameter circles both significantly increased after training (P = 0.0008 and P = 0.0007, respectively). The BCEA encompassing 68.2, 95.4, 99.6% of fixation points were all significantly decreased after training (P = 0.0038, P = 0.0022, and P = 0.0021, respectively). The NEI-VFQ-25 scores were significantly increased at the end of the rehabilitation training (P < 0.0001).
Rehabilitation with MP-3 MBFT is a user-friendly therapeutic option for improving visual function, fixation stability, and quality of life in advanced macular disease.
The prospective study was registered with the Chinese Clinical Trial Registry ( http://www.chictr.org.cn/ ).
ChiCTR2000029586 . Date of registration: 05/02/2020.
评估 MP-3 微视野生物反馈固视训练（MBFT）在伴有中心视力丧失的黄斑病变致低视力患者视功能康复中的疗效。
本前瞻性干预研究纳入了 17 例患者的 17 只眼（年龄相关性黄斑变性 7 只眼，近视性黄斑病变 10 只眼）。通过全面的眼底检查（包括眼底照相、自发荧光、光学相干断层扫描和微视野检查）确定最佳固视点。康复治疗包括每个眼 3 次、每次 10 分钟，每周 2 次，共 20 周，使用 MP-3 微视野计。在训练前后分别记录最佳矫正视力（BCVA）、阅读速度、平均中心敏感度、指定区域内固视点的百分比、双变量轮廓椭圆面积（BCEA）和 25 项国家眼科研究所视功能问卷（NEI-VFQ-25）。
康复后最终 BCVA、阅读速度和平均中心敏感度均显著提高（P<0.0001、P=0.0013 和 P=0.0002）。训练后 2°和 4°直径圆圈内固视点的百分比均显著增加（P=0.0008 和 P=0.0007）。包含 68.2%、95.4%和 99.6%固视点的 BCEA 在训练后均显著减小（P=0.0038、P=0.0022 和 P=0.0021）。康复训练结束时，NEI-VFQ-25 评分显著提高（P<0.0001）。
MP-3 MBFT 康复治疗是一种易于使用的治疗选择，可改善晚期黄斑病变患者的视功能、固视稳定性和生活质量。
前瞻性研究在中国临床试验注册中心（http://www.chictr.org.cn/）注册。注册号：ChiCTR2000029586。注册日期：2020 年 5 月 2 日。
