特发性肺纤维化患者发生静脉血栓栓塞症的风险：一项系统评价和荟萃分析
Risk of venous thromboembolism in patients with idiopathic pulmonary fibrosis: a systematic review and meta-analysis.
作者信息
Boonpheng Boonphiphop, Ungprasert Patompong
机构信息
Department of Internal Medicine, East Tennessee State University, Johnson City, TN, USA.
Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
出版信息
Sarcoidosis Vasc Diffuse Lung Dis. 2018;35(2):109-114. doi: 10.36141/svdld.v35i2.6213. Epub 2018 Apr 28.
Recent studies have suggested that patients with idiopathic pulmonary fibrosis (IPF) may have a higher risk of venous thromboembolism (VTE) compared to general population even though the results were inconsistent. To investigate the risk of VTE among patients with IPF. Comprehensive literature review using MEDLINE and EMBASE database were performed to identify studies that compared the risk of VTE among patients with IPF to general population. Effect estimates from each study were combined together using random effect model, generic inverse variance method of DerSimonian and Laird. Out of 510 retrieved articles, 5 studies met the inclusion criteria and were included in the meta-analysis. A significant risk of VTE in patients with IPF was observed with the pooled risk ratio of 2.11 (95% confidence interval, 1.28-3.48). The heterogeneity was moderate with I of 64%. An approximately 2-fold increased risk of VTE among patients with IPF was observed in this meta-analysis. .
近期研究表明，特发性肺纤维化（IPF）患者发生静脉血栓栓塞（VTE）的风险可能高于普通人群，尽管结果并不一致。为了调查IPF患者发生VTE的风险，我们使用MEDLINE和EMBASE数据库进行了全面的文献综述，以确定比较IPF患者与普通人群VTE风险的研究。采用DerSimonian和Laird的随机效应模型、通用逆方差法将每项研究的效应估计值合并在一起。在检索到的510篇文章中，有5项研究符合纳入标准并被纳入荟萃分析。观察到IPF患者发生VTE的风险显著增加，合并风险比为2.11（95%置信区间，1.28 - 3.48）。异质性为中度，I²为64%。在这项荟萃分析中，观察到IPF患者发生VTE的风险增加了约2倍。
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