Ranjbar Tahereh, Nekooeian Ali Akbar, Tanideh Nader, Koohi-Hosseinabadi Omid, Masoumi Seyed Jalil, Amanat Sasan, Azarpira Negar, Monabati Ahmad
Department of Clinical Nutrition, School of Nutrition and Food Science, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
J Food Biochem. 2020 Aug;44(8):e13242. doi: 10.1111/jfbc.13242. Epub 2020 Jun 1.
The beneficial effects of Stevia on metabolic indices have been studied in recent years. However, controversial results emphasize the need for further investigation. We aimed to examine and compare the effects of Stevia's hydroalcoholic extract with two dosages (200, 400 mg/kg) with those of metformin (100 mg/kg) on metabolic syndrome (MetS) indices of rats fed with a high-fat, high-sucrose diet (HFHS). It was found that both Stevia extract and metformin could prevent the adverse effects of a HFHS on lipid profile, liver enzymes, total antioxidant capacity (TAC), and histopathologic factors. Except for the finding that metformin showed a greater potential to alleviate insulin resistance than did Stevia extract, no significant difference was observed between the rats receiving metformin or Stevia extract. In addition, using a high treatment dosage of Stevia extract did not lead to better results than a low dosage. Collectively, the efficacy of Stevia extracts to modify metabolic, oxidative, and histopathological indices in a MetS model was comparable to that of the metformin. PRACTICAL APPLICATIONS: This study was aimed to compare the efficiency of Stevia hydroalcoholic extract with metformin in attenuating MetS abnormalities of rats induced by a high-fat, high-sucrose diet. The results showed the beneficial changes caused due to the administration of Stevia extract on lipid profile, antioxidant capacity, liver enzyme, and liver histopathological indices. The changes were comparable with the results of metformin group. Despite some promising results, further investigation is suggested to evaluate the effectiveness of Stevia extract on human subjects.
近年来，已对甜叶菊对代谢指标的有益作用进行了研究。然而，有争议的结果强调了进一步研究的必要性。我们旨在研究并比较甜叶菊水醇提取物两种剂量（200、400毫克/千克）与二甲双胍（100毫克/千克）对高脂高糖饮食（HFHS）喂养大鼠代谢综合征（MetS）指标的影响。结果发现，甜叶菊提取物和二甲双胍均可预防HFHS对血脂、肝酶、总抗氧化能力（TAC）和组织病理学因素的不良影响。除了二甲双胍在减轻胰岛素抵抗方面比甜叶菊提取物表现出更大潜力这一发现外，接受二甲双胍或甜叶菊提取物的大鼠之间未观察到显著差异。此外，使用高剂量甜叶菊提取物并未比低剂量产生更好的效果。总体而言，甜叶菊提取物在MetS模型中改善代谢、氧化和组织病理学指标的功效与二甲双胍相当。实际应用：本研究旨在比较甜叶菊水醇提取物与二甲双胍减轻高脂高糖饮食诱导的大鼠MetS异常的效率。结果显示，给予甜叶菊提取物可对血脂、抗氧化能力、肝酶和肝脏组织病理学指标产生有益变化。这些变化与二甲双胍组的结果相当。尽管有一些有前景的结果，但建议进一步研究以评估甜叶菊提取物对人类受试者的有效性。
