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COVID-19 对心力衰竭住院和管理的影响:大流行高峰期伦敦心力衰竭病房的报告。

The impact of COVID-19 on heart failure hospitalization and management: report from a Heart Failure Unit in London during the peak of the pandemic.

机构信息

School of Cardiovascular Medicine and Sciences, King's College London British Heart Foundation Centre of Excellence, James Black Centre, London, UK.

Department of Cardiology, King's College Hospital London, London, UK.

出版信息

Eur J Heart Fail. 2020 Jun;22(6):978-984. doi: 10.1002/ejhf.1925. Epub 2020 Jul 4.

Abstract

AIMS

To examine the impact of COVID-19 on acute heart failure (AHF) hospitalization rates, clinical characteristics and management of patients admitted to a tertiary Heart Failure Unit in London during the peak of the pandemic.

METHODS AND RESULTS

Data from King's College Hospital, London, reported to the National Heart Failure Audit for England and Wales, between 2 March-19 April 2020 were compared both to a pre-COVID cohort and the corresponding time periods in 2017 to 2019 with respect to absolute hospitalization rates. Furthermore, we performed detailed comparison of patients hospitalized during the COVID-19 pandemic and patients presenting in the same period in 2019 with respect to clinical characteristics and management during the index admission. A significantly lower admission rate for AHF was observed during the study period compared to all other included time periods. Patients admitted during the COVID-19 pandemic had higher rates of New York Heart Association III or IV symptoms (96% vs. 77%, P = 0.03) and severe peripheral oedema (39% vs. 14%, P = 0.01). We did not observe any differences in inpatient management, including place of care and pharmacological management of heart failure with reduced ejection fraction.

CONCLUSION

Incident AHF hospitalization significantly declined in our centre during the COVID-19 pandemic, but hospitalized patients had more severe symptoms at admission. Further studies are needed to investigate whether the incidence of AHF declined or patients did not present to hospital while the national lockdown and social distancing restrictions were in place. From a public health perspective, it is imperative to ascertain whether this will be associated with worse long-term outcomes.

摘要

目的

研究 COVID-19 对伦敦一家三级心力衰竭病房因急性心力衰竭(AHF)住院患者的住院率、临床特征和管理的影响。

方法和结果

对比 2020 年 3 月 2 日至 4 月 19 日期间伦敦国王学院医院向英格兰和威尔士国家心力衰竭审计报告的数据,与 COVID-19 前队列和 2017 年至 2019 年同期的绝对住院率相比。此外,我们还详细比较了 COVID-19 大流行期间住院的患者和 2019 年同期住院的患者,比较了他们的临床特征和指数入院期间的管理。与所有其他纳入时间段相比,研究期间 AHF 的入院率明显较低。在 COVID-19 大流行期间入院的患者中,纽约心脏协会 III 或 IV 级症状的发生率更高(96% vs. 77%,P=0.03),外周严重水肿的发生率更高(39% vs. 14%,P=0.01)。我们没有观察到住院管理方面的任何差异,包括心衰射血分数降低患者的护理场所和药物管理。

结论

在 COVID-19 大流行期间,我们中心的新发 AHF 住院显著下降,但住院患者入院时的症状更严重。需要进一步研究,以调查是否因国家封锁和社会隔离限制而导致 AHF 发病率下降或患者未住院。从公共卫生的角度来看,必须确定这是否会与更糟糕的长期预后有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a4a/7300902/bb0a40f77b03/EJHF-22-978-g002.jpg

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