CD38/cADPR 信号通路在阻塞性肺疾病中的作用。
Role of CD38/cADPR signaling in obstructive pulmonary diseases.
机构信息
Departments of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN, United States.
Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN, United States.
出版信息
Curr Opin Pharmacol. 2020 Apr;51:29-33. doi: 10.1016/j.coph.2020.04.007. Epub 2020 May 29.
Abstract
The worldwide socioeconomical burden associated with chronic respiratory diseases is substantial. Enzymes involved in the metabolism of nicotinamide adenine dinucleotide (NAD) are increasingly being implicated in chronic airway diseases. One such enzyme, CD38, utilizes NAD to produce several metabolites, including cyclic ADP ribose (cADPR), which is involved in calcium signaling in airway smooth muscle (ASM). Upregulation of CD38 in ASM caused by exposure to cytokines or allergens leads to enhanced calcium mobilization by agonists and the development of airway hyperresponsiveness (AHR) to contractile agonists. Glucocorticoids and microRNAs can suppress CD38 expression in ASM, whereas cADPR antagonists such as 8Br-cADPR can directly antagonize intracellular calcium mobilization. Bronchodilators act via CD38-independent mechanisms. CD38-dependent mechanisms could be developed for chronic airway diseases therapy.
摘要
与慢性呼吸道疾病相关的全球社会经济负担是巨大的。参与烟酰胺腺嘌呤二核苷酸（NAD）代谢的酶越来越多地与慢性气道疾病有关。其中一种酶，CD38，利用 NAD 产生几种代谢物，包括环 ADP 核糖（cADPR），它参与气道平滑肌（ASM）中的钙信号转导。暴露于细胞因子或过敏原引起的 ASM 中 CD38 的上调导致激动剂增强钙动员和对收缩性激动剂的气道高反应性（AHR）的发展。糖皮质激素和 microRNAs 可以抑制 ASM 中的 CD38 表达，而 cADPR 拮抗剂，如 8Br-cADPR，可以直接拮抗细胞内钙动员。支气管扩张剂通过 CD38 独立机制起作用。可以为慢性气道疾病治疗开发 CD38 依赖性机制。
相似文献
1
Role of CD38/cADPR signaling in obstructive pulmonary diseases.CD38/cADPR 信号通路在阻塞性肺疾病中的作用。
Curr Opin Pharmacol. 2020 Apr;51:29-33. doi: 10.1016/j.coph.2020.04.007. Epub 2020 May 29.
2
Modulation of calcium signaling by interleukin-13 in human airway smooth muscle: role of CD38/cyclic adenosine diphosphate ribose pathway.白细胞介素-13对人气道平滑肌钙信号的调节作用：CD38/环磷酸腺苷二磷酸核糖途径的作用
Am J Respir Cell Mol Biol. 2004 Jul;31(1):36-42. doi: 10.1165/rcmb.2003-0313OC. Epub 2004 Feb 5.
3
Connexin-43 hemichannels mediate cyclic ADP-ribose generation and its Ca2+-mobilizing activity by NAD+/cyclic ADP-ribose transport.缝隙连接蛋白 43 半通道通过 NAD+/环 ADP-核糖转运介导环 ADP-核糖的生成及其动员 Ca2+的活性。
J Biol Chem. 2011 Dec 30;286(52):44480-90. doi: 10.1074/jbc.M111.307645. Epub 2011 Oct 27.
4
CD38/cADPR Signaling Pathway in Airway Disease: Regulatory Mechanisms.CD38/cADPR 信号通路在气道疾病中的作用：调控机制。
Mediators Inflamm. 2018 Feb 7;2018:8942042. doi: 10.1155/2018/8942042. eCollection 2018.
5
Cyclic ADP-ribose requires CD38 to regulate the release of ATP in visceral smooth muscle.环 ADP-核糖需要 CD38 来调节内脏平滑肌中 ATP 的释放。
FEBS J. 2011 Sep;278(17):3095-108. doi: 10.1111/j.1742-4658.2011.08233.x. Epub 2011 Aug 8.
6
Synthesis of the Ca-mobilizing messengers NAADP and cADPR by intracellular CD38 enzyme in the mouse heart: Role in β-adrenoceptor signaling.小鼠心脏中细胞内CD38酶合成钙动员信使NAADP和cADPR：在β-肾上腺素能受体信号传导中的作用
J Biol Chem. 2017 Aug 11;292(32):13243-13257. doi: 10.1074/jbc.M117.789347. Epub 2017 May 24.
7
Mechanism of cyclizing NAD to cyclic ADP-ribose by ADP-ribosyl cyclase and CD38.ADP核糖基环化酶和CD38将烟酰胺腺嘌呤二核苷酸（NAD）环化为环磷酸腺苷核糖（cADPR）的机制。
J Biol Chem. 2009 Oct 2;284(40):27629-36. doi: 10.1074/jbc.M109.030965. Epub 2009 Jul 28.
8
CD38-Cyclic ADP-Ribose Signal System in Physiology, Biochemistry, and Pathophysiology.CD38-环 ADP-核糖信号系统：生理学、生物化学和病理生理学。
Int J Mol Sci. 2022 Apr 13;23(8):4306. doi: 10.3390/ijms23084306.
9
Inhibition of cardiomyocytes differentiation of mouse embryonic stem cells by CD38/cADPR/Ca2+ signaling pathway.CD38/cADPR/Ca2+ 信号通路抑制小鼠胚胎干细胞向心肌细胞的分化。
J Biol Chem. 2012 Oct 12;287(42):35599-35611. doi: 10.1074/jbc.M112.392530. Epub 2012 Aug 20.
10
Cluster of differentiation 38 (CD38) mediates bile acid-induced acinar cell injury and pancreatitis through cyclic ADP-ribose and intracellular calcium release.簇分化抗原 38（CD38）通过环 ADP-核糖和细胞内钙释放介导胆汁酸诱导的腺泡细胞损伤和胰腺炎。
J Biol Chem. 2013 Sep 20;288(38):27128-27137. doi: 10.1074/jbc.M113.494534. Epub 2013 Aug 12.
引用本文的文献
1
Aberrant humoral immune responses and intestinal homeostasis in Cd38 Bst1 double knockout mice.Cd38 Bst1双敲除小鼠的异常体液免疫反应和肠道稳态
Immunohorizons. 2025 Jul 14;9(8). doi: 10.1093/immhor/vlaf029.
2
Immunometabolism: signaling pathways, homeostasis, and therapeutic targets.免疫代谢：信号通路、稳态及治疗靶点
MedComm (2020). 2024 Nov 3;5(11):e789. doi: 10.1002/mco2.789. eCollection 2024 Nov.
3
Cancer stem cells: advances in knowledge and implications for cancer therapy.癌症干细胞：知识进展及其对癌症治疗的影响。
Signal Transduct Target Ther. 2024 Jul 5;9(1):170. doi: 10.1038/s41392-024-01851-y.
4
Causal role of immune cells in obstructive sleep apnea hypopnea syndrome: Mendelian randomization study.免疫细胞在阻塞性睡眠呼吸暂停低通气综合征中的因果作用：孟德尔随机化研究
World J Clin Cases. 2024 Mar 6;12(7):1227-1234. doi: 10.12998/wjcc.v12.i7.1227.
5
Toll/interleukin-1 receptor (TIR) domain-containing proteins have NAD-RNA decapping activity. toll/白细胞介素-1 受体 (TIR) 域蛋白具有 NAD-RNA 脱帽活性。
Nat Commun. 2024 Mar 13;15(1):2261. doi: 10.1038/s41467-024-46499-y.
6
Single-cell immunophenotyping revealed the association of CD4+ central and CD4+ effector memory T cells linking exacerbating chronic obstructive pulmonary disease and NSCLC.单细胞免疫表型分析揭示了 CD4+ 中央记忆和 CD4+ 效应记忆 T 细胞与加重慢性阻塞性肺疾病（COPD）和 NSCLC 的关联。
Front Immunol. 2023 Dec 20;14:1297577. doi: 10.3389/fimmu.2023.1297577. eCollection 2023.
7
Multi-targeted immunotherapeutics to treat B cell malignancies.多靶点免疫疗法治疗 B 细胞恶性肿瘤。
J Control Release. 2023 Jun;358:232-258. doi: 10.1016/j.jconrel.2023.04.048. Epub 2023 May 5.
8
Tryptophan Metabolism 'Hub' Gene Expression Associates with Increased Inflammation and Severe Disease Outcomes in COVID-19 Infection and Inflammatory Bowel Disease.色氨酸代谢“枢纽”基因表达与 COVID-19 感染和炎症性肠病中的炎症增加和严重疾病结局相关。
Int J Mol Sci. 2022 Nov 26;23(23):14776. doi: 10.3390/ijms232314776.
9
Evolving roles of CD38 metabolism in solid tumour microenvironment.CD38 代谢在实体瘤微环境中的作用不断演变。
Br J Cancer. 2023 Feb;128(4):492-504. doi: 10.1038/s41416-022-02052-6. Epub 2022 Nov 17.
10
Differences in Extracellular NAD and NMN Metabolism on the Surface of Vascular Endothelial Cells.血管内皮细胞表面细胞外烟酰胺腺嘌呤二核苷酸（NAD）和烟酰胺单核苷酸（NMN）代谢的差异
Biology (Basel). 2022 Apr 27;11(5):675. doi: 10.3390/biology11050675.
本文引用的文献
1
Sirtuins as novel targets in the pathogenesis of airway inflammation in bronchial asthma.Sirtuins 作为支气管哮喘气道炎症发病机制中的新型靶点。
Eur J Pharmacol. 2019 Dec 15;865:172670. doi: 10.1016/j.ejphar.2019.172670. Epub 2019 Sep 19.
2
Pharmacological treatment and current controversies in COPD.慢性阻塞性肺疾病（COPD）的药物治疗及当前争议
F1000Res. 2019 Aug 29;8. doi: 10.12688/f1000research.19811.1. eCollection 2019.
3
SETD7 promotes TNF-α-induced proliferation and migration of airway smooth muscle cells in vitro through enhancing NF-κB/CD38 signaling.SETD7 通过增强 NF-κB/CD38 信号通路促进 TNF-α 诱导的气道平滑肌细胞的增殖和迁移。
Int Immunopharmacol. 2019 Jul;72:459-466. doi: 10.1016/j.intimp.2019.04.043.
4
PARP inhibition by olaparib alleviates chronic asthma-associated remodeling features via modulating inflammasome signaling in mice.奥拉帕尼通过调节小鼠炎症小体信号减轻慢性哮喘相关重塑特征。
IUBMB Life. 2019 Jul;71(7):1003-1013. doi: 10.1002/iub.2048. Epub 2019 Apr 9.
5
NAD metabolism as a target for metabolic health: have we found the silver bullet?NAD 代谢作为代谢健康的靶点：我们是否找到了银弹？
Diabetologia. 2019 Jun;62(6):888-899. doi: 10.1007/s00125-019-4831-3. Epub 2019 Feb 16.
6
CD38/cADPR Signaling Pathway in Airway Disease: Regulatory Mechanisms.CD38/cADPR 信号通路在气道疾病中的作用：调控机制。
Mediators Inflamm. 2018 Feb 7;2018:8942042. doi: 10.1155/2018/8942042. eCollection 2018.
7
Association of Inhaled Corticosteroids and Long-Acting β-Agonists as Controller and Quick Relief Therapy With Exacerbations and Symptom Control in Persistent Asthma: A Systematic Review and Meta-analysis.吸入性糖皮质激素与长效β受体激动剂联合作为持续性哮喘控制和快速缓解治疗与病情加重及症状控制的关联：一项系统评价和荟萃分析
JAMA. 2018 Apr 10;319(14):1485-1496. doi: 10.1001/jama.2018.2769.
8
High-fat-diet induces airway hyperresponsiveness partly through activating CD38 signaling pathway.高脂饮食通过激活 CD38 信号通路部分诱导气道高反应性。
Int Immunopharmacol. 2018 Mar;56:197-204. doi: 10.1016/j.intimp.2018.01.033. Epub 2018 Feb 2.
9
The Economic Burden of Asthma in the United States, 2008-2013.美国 2008-2013 年哮喘经济负担
Ann Am Thorac Soc. 2018 Mar;15(3):348-356. doi: 10.1513/AnnalsATS.201703-259OC.
10
CD38 modulates respiratory syncytial virus-driven proinflammatory processes in human monocyte-derived dendritic cells.CD38 调节人单核细胞来源树突状细胞中呼吸道合胞病毒驱动的促炎过程。
Immunology. 2018 May;154(1):122-131. doi: 10.1111/imm.12873. Epub 2017 Dec 18.
Zotero 插件