手术引起的体重减轻对血管内皮功能障碍生物标志物的影响：系统评价和荟萃分析。
Effect of Surgically Induced Weight Loss on Biomarkers of Endothelial Dysfunction: a Systematic Review and Meta-Analysis.
机构信息
Department of Medical Surgical Nursing, School of Nursing & Midwifery, Tehran University of Medical Sciences, Tehran, Iran.
Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Obes Surg. 2020 Sep;30(9):3549-3560. doi: 10.1007/s11695-020-04710-1.
BACKGROUND
This meta-analysis was performed to assess the effects of bariatric surgery (BS) on the selected markers of endothelial dysfunction, including monocyte chemoattractant protein-1 (MCP-1), intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin.
METHODS
PubMed, Scopus, and Google scholar were systematically searched to identify related studies published from inception to November 2019 to find eligible studies.
RESULTS
A total of 29 different studies were included. BS reduced the concentrations of MCP-1 (weighted mean difference (WMD) = - 58.91; 95%CI (confidence interval), - 77.10 to - 40.72; P = ˂ 0.001), ICAM-1 (WMD = - 36.58; 95%CI, - 49.65 to - 23.52; P = ˂ 0.001), and E-selectin (WMD = - 11.22; 95%CI, - 14.43 to - 8.01; P < 0.001), but had no significant effect on VCAM-1.
CONCLUSION
Bariatric surgery reduces circulating concentration of MCP-1, ICAM-1, and E-selectin, but not VCAM-1.
背景
本荟萃分析旨在评估减重手术（BS）对选定的内皮功能障碍标志物（包括单核细胞趋化蛋白-1（MCP-1）、细胞间黏附分子 1（ICAM-1）、血管细胞黏附分子 1（VCAM-1）和 E-选择素）的影响。
方法
系统检索了 PubMed、Scopus 和 Google Scholar，以查找从开始到 2019 年 11 月发表的相关研究，以找到合格的研究。
结果
共纳入 29 项不同的研究。BS 降低了 MCP-1（加权均数差（WMD）= -58.91；95%置信区间（CI），-77.10 至-40.72；P ˂ 0.001）、ICAM-1（WMD = -36.58；95%CI，-49.65 至-23.52；P ˂ 0.001）和 E-选择素（WMD = -11.22；95%CI，-14.43 至-8.01；P ˂ 0.001）的浓度，但对 VCAM-1 没有显著影响。
结论
减重手术可降低循环 MCP-1、ICAM-1 和 E-选择素的浓度，但对 VCAM-1 无影响。
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