Alizadeh Shahab, Mirzaei Khadijeh, Mohammadi Chonur, Keshavarz Seyed Ali, Maghbooli Zhila
Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, TUMS, Tehran, Iran.
Arch Endocrinol Metab. 2017 Dec;61(6):567-574. doi: 10.1590/2359-3997000000269. Epub 2017 Jun 26.
Adipokines are mediators of body composition and are involved in obesity complications. This study aimed to assess the association of circulating omentin-1, vaspin, and RBP-4 with body composition indices and metabolic health status (MHS) in different phenotypes of body size.
A total of 350 subjects were included in the current cross-sectional study. Body composition was measured using a body composition analyzer, and serum concentrations of omentin-1, vaspin, and RBP-4 were assessed by ELISA kits.
Circulating omentin-1 was significantly (OR = 1.81, 95% CI: 1.00-1.91, P = 0.01) and marginally (OR = 1.63, 95%CI: 1.00-1.75, P = 0.06) associated with MHS in the overweight and obese subjects, respectively. But no association was seen between omentin-1 and MHS in normal-weight subjects. Serum levels of vaspin and RBP-4 were not correlated with MHS. Furthermore, a significant positive correlation was observed between circulating omentin-1 and body mass index (BMI) as well as fat percentage (P = 0.02) in the MHS group. Serum vaspin concentrations were not related to body composition components in both groups. In addition, in the MHS group, circulating RBP-4 was positively correlated with fat percentage and fat mass (FM) (p < 0.0001) and was negatively correlated with fat-free mass (FFM) and total body water (TBW) (p < 0.0001). In contrast, in the metabolically unhealthy group, RBP-4 was negatively correlated with fat percentage, FM, and BMI (p < 0.0001) and was positively correlated with FFM and TBW (p < 0.0001).
This study showed that circulating levels of omentin-1 are useful predictors of metabolic health status in overweight and obese people.
脂肪因子是身体成分的介质，参与肥胖并发症。本研究旨在评估循环中的网膜素-1、内脏脂肪素和视黄醇结合蛋白-4与不同体型表型的身体成分指标和代谢健康状况（MHS）之间的关联。
本横断面研究共纳入350名受试者。使用身体成分分析仪测量身体成分，并用酶联免疫吸附测定试剂盒评估血清中网膜素-1、内脏脂肪素和视黄醇结合蛋白-4的浓度。
在超重和肥胖受试者中，循环中的网膜素-1分别与MHS显著相关（OR = 1.81，95%CI：1.00 - 1.91，P = 0.01）和边缘相关（OR = 1.63，95%CI：1.00 - 1.75，P = 0.06）。但在正常体重受试者中，未发现网膜素-1与MHS之间存在关联。血清内脏脂肪素和视黄醇结合蛋白-4水平与MHS无关。此外，在MHS组中，循环中的网膜素-1与体重指数（BMI）以及脂肪百分比之间存在显著正相关（P = 0.02）。两组中血清内脏脂肪素浓度均与身体成分组分无关。此外，在MHS组中，循环中的视黄醇结合蛋白-4与脂肪百分比和脂肪量（FM）呈正相关（p < 0.0001），与去脂体重（FFM）和总体水（TBW）呈负相关（p < 0.0001）。相比之下，在代谢不健康组中，视黄醇结合蛋白-4与脂肪百分比、FM和BMI呈负相关（p < 0.0001），与FFM和TBW呈正相关（p < 0.0001）。
本研究表明，循环中的网膜素-1水平是超重和肥胖人群代谢健康状况的有用预测指标。
