Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan 8174673461, Iran.
Cardiac Rehabilitation Research center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan 8174673461, Iran.
Phytomedicine. 2021 Jan;80:153359. doi: 10.1016/j.phymed.2020.153359. Epub 2020 Sep 29.
Cardiovascular diseases, obesity, and insulin resistance demonstrate elements of functional impairment of the endothelium. Treatment of endothelial dysfunction with natural products, such as pomegranate, can open new ways in the treatment of cardiovascular diseases.
The present meta-analysis provides information in highlighting the role of pomegranate in endothelial dysfunction.
Various databases, such as PubMed, Scopus, Web of Science, Cochrane, and Google Scholar, were searched up to July 2020 using relevant keywords. We have selected the studies that investigated the effects of pomegranate on vascular adhesion factors, including intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), E-selectin, and interleukin-6 (IL-6). MD with 95% CrI with 100,000 iterations by using Markov chain Monte Carlo code were used.
Pooled effect size of articles in human studies indicated that pomegranate juice was not significantly effective on ICAM-1 [MD: -0.42; CrI: (-1.01, 0.17)], VCAM-1 [MD: -0.20; CrI: (-1.95, 1.40)], and E-selectin [MD: -0.21; CrI: (-1.62, 1.21)] compared to the control group. But it can significantly reduce IL-6 [MD: -1.07; CrI: (-1.90, -0.19)].
Generally, present study showed that pomegranate juice has no significant effect on vascular adhesion factors, ICAM-1, VCAM-1, and E-selectin, but can reduce IL-6 significantly. Future prospective randomized clinical trials with longer intervention duration are warranted to obtain a precise conclusion.
心血管疾病、肥胖和胰岛素抵抗表现出内皮功能障碍的特征。使用石榴等天然产物治疗内皮功能障碍可能为心血管疾病的治疗开辟新途径。
本荟萃分析提供了有关石榴在内皮功能障碍中的作用的信息。
使用相关关键字，在各种数据库（如 PubMed、Scopus、Web of Science、Cochrane 和 Google Scholar）中搜索至 2020 年 7 月的信息。我们选择了研究石榴对血管黏附因子（包括细胞间黏附分子 1（ICAM-1）、血管细胞黏附分子 1（VCAM-1）、E-选择素和白细胞介素-6（IL-6））影响的研究。使用 Markov 链蒙特卡罗代码进行 100,000 次迭代的 MD 与 95% CrI。
纳入的人类研究文章的汇总效应大小表明，石榴汁与对照组相比，对 ICAM-1[MD：-0.42；CrI：(-1.01, 0.17)]、VCAM-1[MD：-0.20；CrI：(-1.95, 1.40)]和 E-选择素[MD：-0.21；CrI：(-1.62, 1.21)]无显著作用。但它可以显著降低 IL-6[MD：-1.07；CrI：(-1.90, -0.19)]。
总体而言，本研究表明石榴汁对血管黏附因子、ICAM-1、VCAM-1 和 E-选择素无显著作用，但可显著降低 IL-6。需要进行更长干预时间的前瞻性随机临床试验以得出更准确的结论。
