宿主与念珠菌相互作用的系统生物学：理解我们如何相互影响。
Systems biology of host-Candida interactions: understanding how we shape each other.
作者信息
Hodgins-Davis Andrea, O'Meara Teresa R
机构信息
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
出版信息
Curr Opin Microbiol. 2020 Dec;58:1-7. doi: 10.1016/j.mib.2020.04.001. Epub 2020 May 30.
Candida albicans is both a member of the human mucosal microbiota and a common agent of invasive fungal disease. Systems biology approaches allow for analysis of the interactions between this fungus and its mammalian host. Framing these studies by considering how C. albicans and its host construct the niche the other occupies provides insight into how these interactions shape the ecosystems, behavior, and evolution of each organism. Here, we discuss recent work on multiscale systems biology approaches for examining C. albicans in relation to the host ecosystem to identify the emergent properties of the interactions and new variables that can be targeted for development of therapeutic strategies.
白色念珠菌既是人类黏膜微生物群的成员，也是侵袭性真菌病的常见病原体。系统生物学方法有助于分析这种真菌与其哺乳动物宿主之间的相互作用。通过考虑白色念珠菌及其宿主如何构建对方所占据的生态位来构建这些研究，能够深入了解这些相互作用如何塑造每个生物体的生态系统、行为和进化。在这里，我们讨论了最近关于多尺度系统生物学方法的研究工作，这些方法用于研究白色念珠菌与宿主生态系统的关系，以确定相互作用的涌现特性以及可作为治疗策略开发靶点的新变量。
Zotero 插件