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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Karhumäki E, Marnela K M, Krohn K

Institute of Biomedical Sciences, University of Tampere, Finland.

Int J Biochem. 1988;20(10):1067-72. doi: 10.1016/0020-711x(88)90251-0.

The effect of dialysable transfer factor (TFd), derived from human leukocytes or porcine spleen cells, was measured using Listeria resistance in mice. 2. The molecular weight range of substance(s) containing TF-like activity is in the less than 3500 MW dialysis fraction on the basis of the capacity of peritoneal macrophages to produce superoxide anion (O2-). This biological activity is removed by heating at 56 degrees C. 3. After Sephadex G-10 chromatography of dialysates the significant activities are found in fractions III and IV of human leukocyte dialysate and in fractions of II and III of porcine spleen dialysate. 4. From enzymatic studies, most of the protective activity of both human leukocyte and porcine spleen dialysate is based on the action of small-molecular weight structures containing peptides and/or polynucleotides.

使用小鼠对李斯特菌的抵抗力来测定源自人白细胞或猪脾细胞的可透析转移因子（TFd）的效果。2. 根据腹膜巨噬细胞产生超氧阴离子（O2-）的能力，含有TF样活性的物质的分子量范围在分子量小于3500的透析组分中。这种生物活性在56℃加热后会被消除。3. 在对透析液进行葡聚糖G - 10柱色谱分析后，在人白细胞透析液的组分III和IV以及猪脾透析液的组分II和III中发现了显著活性。4. 从酶学研究来看，人白细胞和猪脾透析液的大部分保护活性基于含有肽和/或多核苷酸的小分子结构的作用。

Karhumäki E, Marnela K M, Krohn K

Institute of Biomedical Sciences, University of Tampere, Finland.

Int J Biochem. 1988;20(10):1067-72. doi: 10.1016/0020-711x(88)90251-0.

The effect of dialysable transfer factor (TFd), derived from human leukocytes or porcine spleen cells, was measured using Listeria resistance in mice. 2. The molecular weight range of substance(s) containing TF-like activity is in the less than 3500 MW dialysis fraction on the basis of the capacity of peritoneal macrophages to produce superoxide anion (O2-). This biological activity is removed by heating at 56 degrees C. 3. After Sephadex G-10 chromatography of dialysates the significant activities are found in fractions III and IV of human leukocyte dialysate and in fractions of II and III of porcine spleen dialysate. 4. From enzymatic studies, most of the protective activity of both human leukocyte and porcine spleen dialysate is based on the action of small-molecular weight structures containing peptides and/or polynucleotides.

使用小鼠对李斯特菌的抵抗力来测定源自人白细胞或猪脾细胞的可透析转移因子（TFd）的效果。2. 根据腹膜巨噬细胞产生超氧阴离子（O2-）的能力，含有TF样活性的物质的分子量范围在分子量小于3500的透析组分中。这种生物活性在56℃加热后会被消除。3. 在对透析液进行葡聚糖G - 10柱色谱分析后，在人白细胞透析液的组分III和IV以及猪脾透析液的组分II和III中发现了显著活性。4. 从酶学研究来看，人白细胞和猪脾透析液的大部分保护活性基于含有肽和/或多核苷酸的小分子结构的作用。