Shanghai Key Lab of Advanced High-temperature Materials and Precision Forming, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Department of Dental Implantology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China; National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai 200011, China.
Mater Sci Eng C Mater Biol Appl. 2020 Aug;113:110959. doi: 10.1016/j.msec.2020.110959. Epub 2020 Apr 12.
Developing new materials with high strength and ductility, low modulus and high biocompatibility is a continuing demand in the field of surgical implants. Inspired by the high-entropy design philosophy, two medium entropy alloys (MEAs), i.e. equiatomic TiZrHf and equi-weight TiZrHfNbTa were designed and their mechanical properties and biocompatibility were assessed. Both the single-phase hexagonal close-packed (HCP) structured TiZrHf alloy and the single-phase body-centered cubic (BCC) structured TiZrHfNbTa alloy show high strength-ductility combinations close to commercial Ti-6Al-4V wrought alloy and remarkably lower young's modulus than commercial pure titanium (CP-Ti) and Ti-6Al-4V. From the aspects of adhesion, proliferation, toxicity and related gene expression of human gingival fibroblasts (HGFs), the TiZrHfNbTa alloy exhibits distinctively better biocompatibility than that of CP-Ti while the TiZrHf shows only slightly better biocompatibility as compared with CP-Ti. These results indicate that these two ductile MEAs are potential candidates for dental application.
开发高强度、高延展性、低模量和高生物相容性的新材料是外科植入物领域的持续需求。受高熵设计理念的启发，设计了两种中熵合金（MEA），即等原子比 TiZrHf 和等重量比 TiZrHfNbTa，并评估了它们的力学性能和生物相容性。单相六方密排（HCP）结构的 TiZrHf 合金和单相体心立方（BCC）结构的 TiZrHfNbTa 合金均表现出接近商用 Ti-6Al-4V 锻件的高强度-延展性组合，并且杨氏模量显著低于商用纯钛（CP-Ti）和 Ti-6Al-4V。从人牙龈成纤维细胞（HGFs）的粘附、增殖、毒性和相关基因表达等方面来看，TiZrHfNbTa 合金的生物相容性明显优于 CP-Ti，而 TiZrHf 与 CP-Ti 相比仅略好一些。这些结果表明，这两种延展性 MEA 是牙科应用的潜在候选材料。
