BioScience and Bioengineering Research (BioSciBer), Bernal Biomaterials, Bernal Institute, University of Limerick, Limerick, Ireland; School of Engineering, University of Limerick, Limerick, Ireland.
Department of Chemical Sciences, University of Limerick, Limerick, Ireland.
Mater Sci Eng C Mater Biol Appl. 2020 Aug;113:110985. doi: 10.1016/j.msec.2020.110985. Epub 2020 Apr 23.
Delivering therapeutics to disease sites is a challenge facing modern medicine. Nanoparticle delivery systems are of considerable interest to overcome this challenge, but these systems suffer from poor clinical translation. It is believed this is, in part, due to incomplete understanding of nanoparticle physico-chemical properties in vivo. To understand how nanoparticle properties could change following intravenous delivery, Au, Ag, FeO, TiO, and ZnO nanoparticles of 5, 20, and 50 nm were characterised in water and physiological fluids. The effects of the dispersion medium, concentration, and incubation time on size, dispersion, and zeta potential were measured. Properties varied significantly depending on material type, size, and concentration over 24 h. Gold and silver nanoparticles were generally the most stable. Meanwhile, 20 nm nanoparticles appeared to be the least stable size, across materials. These results could have important implications for selecting nanoparticles for drug delivery that will elicit the desired physiological response.
将治疗药物递送到疾病部位是现代医学面临的挑战。纳米粒子递药系统是克服这一挑战的重要研究方向，但这些系统在临床转化方面效果不佳。人们认为，这在一定程度上是由于对体内纳米粒子的物理化学性质缺乏完整的认识。为了了解静脉注射给药后纳米粒子的性质如何变化，我们对 5nm、20nm 和 50nm 的金、银、FeO、TiO 和 ZnO 纳米粒子在水中和生理液中的性质进行了研究。测量了分散介质、浓度和孵育时间对粒径、分散性和 zeta 电位的影响。结果表明，在 24 小时内，材料类型、粒径和浓度对性质的影响显著。金和银纳米粒子通常最稳定。同时，20nm 纳米粒子在各种材料中似乎是最不稳定的粒径。这些结果对于选择用于药物递送的纳米粒子以产生所需的生理反应可能具有重要意义。
