氧化应激不影响成年人有氧运动训练引起的体重减轻：随机临床试验

Oxidative stress does not influence weight loss induced by aerobic training in adults: randomized clinical trials.

作者信息

Cardoso Glêbia A, Ribeiro Mateus D, Ferreira Ana P, de Oliveira Yohanna, Medeiros Thiago de O, de Sousa Bruno R, Pereira Reabias de A, de Almeida Antônio E, Filho João M, Brito Silva Raquel S, Silva Alexandre S

机构信息

Laboratory of Applied Studies in Physical Training to Performance and Health - LETFADS, Department of Physical Education, Federal University of Paraíba, João Pessoa, PB, Brazil.

Department of Physical Education, Federal University of Paraíba, João Pessoa, PB, Brazil.

出版信息

J Sports Med Phys Fitness. 2020 Jun;60(6):875-882. doi: 10.23736/S0022-4707.20.10528-0.

DOI:10.23736/S0022-4707.20.10528-0

PMID:32487982

Abstract

BACKGROUND

High levels of oxidative stress promote degradation of the cell membrane impairing cellular function in fat oxidation. However, the influence of oxidative stress on exercise-induced weight-loss has not yet been investigated. Therefore, the aim of this study was to verify the influence of a lipidic peroxidation marker (malondialdehyde, MDA) and antioxidant status (total antioxidant capacity marker, TAC) on the magnitude of weight-loss by aerobic-induced exercise in previously sedentary overweight or obese individuals.

METHODS

Seventy-five physically inactive adults were randomized into experimental (N.=58) and control (N.=17) groups, who engaged in a 12-week program of aerobic training walking and/or running (3 to 5 days/week) or stretching (1 day/week), respectively. Body composition (DXA), aerobic capacity (ergospirometric) and blood collections for oxidative stress analysis (MDA and TAC) were determined before and after the experimental protocol. Two-way ANOVA for repeated measures or Friedman's test were used to evaluate differences in time/group interaction. Pearson correlation was used to verify the relationship between the variables of oxidative stress and of body composition.

RESULTS

Significant reduction was found in fat body mass of experimental when compared to control group (-1.3±1.9 kg versus -0.3±1.3, P=0.04). Experimental group also altered significantly the total body mass (-1.2±4.7 kg; effect size 0.44), body mass index - BMI (-0.3±1.1 effect size 0.37), fat percentage (1.3±1.6%; effect size 0.50) and lean body mass (0.6±1.5 kg; effect size 0.32).There was increase in MDA of 2.3 μmol/L to 2.7 μmol/L (P=0.00), without changes to TAC (25.6±13.9% to 28.0±10.4%). No correlation was found between these variations in body composition with either the initial values of MDA and TAC or delta variation of these indicators of oxidative stress in response to the training program.

CONCLUSIONS

Indicators of oxidative stress (MDA and TAC) does not influence the magnitude of weight-loss induced by aerobic training.

摘要

背景

高水平的氧化应激会促进细胞膜降解，损害脂肪氧化中的细胞功能。然而，氧化应激对运动诱导的体重减轻的影响尚未得到研究。因此，本研究的目的是验证脂质过氧化标志物（丙二醛，MDA）和抗氧化状态（总抗氧化能力标志物，TAC）对先前久坐不动的超重或肥胖个体进行有氧运动诱导的体重减轻幅度的影响。

方法

75名身体不活跃的成年人被随机分为实验组（N = 58）和对照组（N = 17），分别进行为期12周的有氧训练步行和/或跑步（每周3至5天）或伸展运动（每周1天）。在实验方案前后测定身体成分（双能X线吸收法）、有氧能力（运动肺量计）以及用于氧化应激分析的血液采集（MDA和TAC）。使用重复测量的双向方差分析或弗里德曼检验来评估时间/组交互作用的差异。使用皮尔逊相关性来验证氧化应激变量与身体成分变量之间的关系。

结果

与对照组相比，实验组的体脂肪量显著减少（-1.3±1.9千克对-0.3±1.3千克，P = 0.04）。实验组还显著改变了总体重（-1.2±4.7千克；效应大小0.44）、体重指数 - BMI（-0.3±1.1；效应大小0.37）、脂肪百分比（1.3±1.6%；效应大小0.50）和去脂体重（0.6±1.5千克；效应大小0.32）。MDA从2.3微摩尔/升增加到2.7微摩尔/升（P = 0.00），TAC没有变化（25.6±13.9%至28.0±10.4%）。在这些身体成分变化与MDA和TAC的初始值或这些氧化应激指标对训练计划的变化量之间未发现相关性。