Youssef Hala, Groussard Carole, Lemoine-Morel Sophie, Pincemail Joel, Jacob Christophe, Moussa Elie, Fazah Abdallah, Cillard Josiane, Pineau Jean-Claude, Delamarche Arlette
Laboratory of Movement, Sport, and Health (M2S), University of Rennes 2, Rennes, France.
Pediatr Exerc Sci. 2015 Feb;27(1):67-76. doi: 10.1123/pes.2014-0008. Epub 2014 Nov 10.
This study aimed to determine whether aerobic training could reduce lipid peroxidation and inflammation at rest and after maximal exhaustive exercise in overweight/obese adolescent girls. Thirty-nine adolescent girls (14-19 years old) were classified as nonobese or overweight/obese and then randomly assigned to either the nontrained or trained group (12-week multivariate aerobic training program). Measurements at the beginning of the experiment and at 3 months consisted of body composition, aerobic fitness (VO2peak) and the following blood assays: pre- and postexercise lipid peroxidation (15F2a-isoprostanes [F2-Isop], lipid hydroperoxide [ROOH], oxidized LDL [ox-LDL]) and inflammation (myeloperoxidase [MPO]) markers. In the overweight/ obese group, the training program significantly increased their fat-free mass (FFM) and decreased their percentage of fat mass (%FM) and hip circumference but did not modify their VO2peak. Conversely, in the nontrained overweight/obese group, weight and %FM increased, and VO2peak decreased, during the same period. Training also prevented exercise-induced lipid peroxidation and/or inflammation in overweight/obese girls (F2-Isop, ROOH, ox-LDL, MPO). In addition, in the trained overweight/obese group, exercise-induced changes in ROOH, ox-LDL and F2-Isop were correlated with improvements in anthropometric parameters (waist-to-hip ratio, %FM and FFM). In conclusion aerobic training increased tolerance to exercise-induced oxidative stress in overweight/obese adolescent girls partly as a result of improved body composition.
本研究旨在确定有氧训练是否能够降低超重/肥胖青春期女孩在静息状态以及最大力竭运动后的脂质过氧化和炎症水平。39名青春期女孩（14 - 19岁）被分为非肥胖组或超重/肥胖组，然后随机分配到非训练组或训练组（为期12周的多变量有氧训练计划）。在实验开始时和3个月时进行的测量包括身体成分、有氧适能（最大摄氧量）以及以下血液检测：运动前后的脂质过氧化（15F2a - 异前列腺素 [F2 - 异前列腺素]、脂质过氧化氢 [ROOH]、氧化型低密度脂蛋白 [ox - LDL]）和炎症（髓过氧化物酶 [MPO]）标志物。在超重/肥胖组中，训练计划显著增加了她们的去脂体重（FFM），降低了她们的体脂百分比（%FM）和臀围，但未改变她们的最大摄氧量。相反，在未训练的超重/肥胖组中，同期体重和%FM增加，最大摄氧量降低。训练还预防了超重/肥胖女孩运动诱导的脂质过氧化和/或炎症（F2 - 异前列腺素、ROOH、ox - LDL、MPO）。此外，在训练后的超重/肥胖组中，运动诱导的ROOH、ox - LDL和F2 - 异前列腺素变化与人体测量参数（腰臀比、%FM和FFM）的改善相关。总之，有氧训练提高了超重/肥胖青春期女孩对运动诱导氧化应激的耐受性，部分原因是身体成分得到改善。
