College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing 100048, P. R. China.
Analyst. 2020 Jun 21;145(12):4111-4123. doi: 10.1039/d0an00392a. Epub 2020 Jun 3.
The drive for a simultaneous analysis of multiple targets with excellent accuracy and efficiency, which is often required in both basic biomedical research and clinical applications, demands the development of multiplexed bioassays with desired throughput. With the development of nanotechnologies, innovative multiplex optical bioassays have been achieved. Nanomaterials exhibit unique physical and chemical properties such as easily tunable size, large surface-to-volume ratio, excellent catalysis and the desired signal transduction mechanism, which makes them excellent candidates for the fabrication of novel optical nanoprobes. This mini review summarizes nanomaterial-based optical multiplex sensors from the last 5 years. Specific optical techniques covered in this review are fluorescence, surface-enhanced Raman scattering (SERS), localized surface plasmon resonance (LSPR), chemiluminescence (CL), and the multimodality with fundamentals and examples.
人们希望在生物医学基础研究和临床应用中，同时分析多个目标并达到出色的准确性和高效率，这一需求推动了高通量的多重生物分析方法的发展。随着纳米技术的发展，创新性的多重光学生物分析方法已经得以实现。纳米材料具有独特的物理和化学性质，例如易于调节的尺寸、大的表面积与体积比、出色的催化作用以及理想的信号转导机制，这些性质使它们成为新型光学纳米探针制造的绝佳选择。本综述总结了过去 5 年来基于纳米材料的光学多重传感器。本文涵盖的具体光学技术包括荧光、表面增强拉曼散射（SERS）、局域表面等离子体共振（LSPR）、化学发光（CL），以及多模态技术，并介绍了其基本原理和应用实例。
