Department of Pediatrics, Faculty of Medicine, Urmia University of Medical Sciences , Urmia, Iran.
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Urmia University of Medical Sciences , Urmia, Iran.
Paediatr Int Child Health. 2020 Aug;40(3):181-185. doi: 10.1080/20469047.2020.1771244. Epub 2020 Jun 3.
A link between vitamin D deficiency and susceptibility to bacterial and viral infections has recently been suggested.
To investigate a possible association between vitamin D deficiency and urinary tract infection (UTI).
A case-control study was undertaken comprising 75 children aged 2-7 years with UTI (cases) compared with 75 healthy controls in terms of serum 25 hydroxyvitamin D [25(OH)D] levels. Serum 25(OH)D levels were measured using a chemiluminescence assay. For cases, dimercaptosuccinic acid (DMSA) renal scan was used as the gold standard to distinguish between acute lower UTI (cystitis) and acute pyelonephritis.
Median (IQR) 25(OH)D levels were lower in the UTI group [14.5 ng/mL (9.4-18.8)] than in the controls [27 ng/mL (22.4-39.0)] (< 0.001). In addition, the prevalence of 25(OH)D levels <20 ng/mL was higher in the children with UTI than in the controls (68% 18%) (< 0.001). There was a statistically significant difference between the cystitis and pyelonephritis groups in mean (SD) serum 25(OH)D levels-18.76 (9.35) ng/mL 13.94 (6.97) ng/mL, < 0.05, respectively.
Low serum vitamin D is associated with UTI and supports the hypothesis that children with low vitamin D levels could be at greater risk of UTI.
最近有研究表明，维生素 D 缺乏与细菌和病毒感染易感性之间存在关联。
研究维生素 D 缺乏与尿路感染（UTI）之间是否存在关联。
采用病例对照研究，纳入 75 例 2-7 岁 UTI 患儿（病例组）和 75 例健康儿童（对照组），比较两组血清 25 羟维生素 D [25(OH)D]水平。采用化学发光法检测血清 25(OH)D 水平。对于病例组，采用二巯丁二酸（DMSA）肾扫描作为金标准，以区分急性下尿路感染（膀胱炎）和急性肾盂肾炎。
UTI 组的血清 25(OH)D 中位数（IQR）[14.5ng/ml（9.4-18.8）]明显低于对照组[27ng/ml（22.4-39.0）]（<0.001）。此外，UTI 患儿中血清 25(OH)D 水平<20ng/ml 的比例（68%比 18%）明显高于对照组（<0.001）。膀胱炎组和肾盂肾炎组的血清 25(OH)D 水平均值（SD）分别为-18.76（9.35）ng/ml 和-13.94（6.97）ng/ml，差异有统计学意义（<0.05）。
血清维生素 D 水平降低与 UTI 相关，支持维生素 D 水平较低的儿童发生 UTI 的风险可能更高的假说。
