Tekin Mehmet, Konca Capan, Celik Velat, Almis Habip, Kahramaner Zelal, Erdemir Aydin, Gulyuz Abdulgani, Uckardes Fatih, Turgut Mehmet
Department of Pediatrics, School of Medicine, Adiyaman University, Adiyaman, Turkey.
Horm Res Paediatr. 2015;83(3):198-203. doi: 10.1159/000370046. Epub 2015 Jan 28.
We aimed to examine whether there is any association between serum levels of 25-hydroxyvitamin D [25(OH)D3] and urinary tract infection (UTI) among children.
White blood cell count, serum C-reactive protein, calcium, phosphorus, alkaline phosphatase, parathormone, and serum 25(OH)D3 levels were measured in 82 children experiencing a first episode of UTI, with no risk factors for UTI, and 64 healthy control children.
The mean serum levels of 25(OH)D3 among children with UTI were significantly lower than those of controls (11.7 ± 3.3 vs. 27.6 ± 4.7 ng/ml; p < 0.001). The serum levels of 25(OH)D3 were significantly lower in patients with acute pyelonephritis compared to patients with lower UTI (8.6 ± 2.8 vs. 14.2 ± 3.0 ng/ml; p < 0.001). Within the study group, mean serum levels of 25(OH)D3 among girls were lower than those of boys (10.9 ± 3.4 ng/ml vs. 13.2 ± 4.4 ng/ml; p < 0.001). Multivariate analysis showed that a serum 25(OH)D3 level of <20 ng/ml (odds ratio 3.503, 95% confidence interval 1.621-7.571; p = 0.001) was associated with UTI in children.
Our results suggest that vitamin D deficiency may be a risk factor for UTI in children.
我们旨在研究儿童血清25-羟维生素D[25(OH)D3]水平与尿路感染（UTI）之间是否存在关联。
对82例首次发生UTI且无UTI危险因素的儿童以及64例健康对照儿童进行白细胞计数、血清C反应蛋白、钙、磷、碱性磷酸酶、甲状旁腺激素和血清25(OH)D3水平检测。
UTI患儿的血清25(OH)D3平均水平显著低于对照组（11.7±3.3对27.6±4.7 ng/ml；p<0.001）。与下尿路感染患者相比，急性肾盂肾炎患者的血清25(OH)D3水平显著降低（8.6±2.8对14.2±3.0 ng/ml；p<0.001）。在研究组中，女孩的血清25(OH)D3平均水平低于男孩（10.9±3.4 ng/ml对13.2±4.4 ng/ml；p<0.001）。多变量分析显示，血清25(OH)D3水平<20 ng/ml（比值比3.503，95%置信区间1.621 - 7.571；p = 0.001）与儿童UTI相关。
我们的结果表明，维生素D缺乏可能是儿童UTI的一个危险因素。
