Department of Nephrology, Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, 519000, Guangdong province, China.
Department of Neurology, Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine, Zhuhai, 519000, Guangdong province, China.
Infection. 2022 Jun;50(3):739-746. doi: 10.1007/s15010-021-01750-2. Epub 2022 Jan 10.
We aimed to explore the association between urinary tract infection (UTI) in adults and serum 25-hydroxyvitamin D (25OHD), which was used to access vitamin D status.
Serum levels of 25OHD were retrospectively analyzed in 234 subjects (190 females and 44 males): 120 UTI patients (females = 103) and 114 age- and sex-matched healthy controls (females = 87). Serum 25OHD concentrations were categorized as follows: (1) < 20 ng/mL, 20 to < 30 ng/mL, and ≥ 30 ng/mL; (2) < 20 ng/mL and ≥ 20 ng/mL.
Serum 25OHD levels were lower in patients with UTI (p < 0.01). Women with UTI presented significantly lower 25OHD concentrations than those without UTI (p < 0.01). No association between serum 25OHD levels and UTI in men was found (p > 0.05). The multivariable logistic regression models showed significant associations between UTI and 25OHD, female sex, neutrophilic lymphocyte ratio and C-reactive protein (p < 0.05).
Lower 25OHD concentrations associated with UTI were most prominent among women. The associations between UTI and low serum 25OHD levels as well as female sex were independent of each other.
本研究旨在探讨成人下尿路感染（UTI）与血清 25-羟维生素 D（25OHD）的关系，25OHD 用于评估维生素 D 状况。
回顾性分析了 234 例患者（190 名女性和 44 名男性）的血清 25OHD 水平，其中 120 例 UTI 患者（女性 103 例）和 114 例年龄和性别匹配的健康对照者（女性 87 例）。血清 25OHD 浓度分为以下几类：（1）<20ng/mL、20-<30ng/mL 和≥30ng/mL；（2）<20ng/mL 和≥20ng/mL。
UTI 患者的血清 25OHD 水平较低（p<0.01）。UTI 女性患者的 25OHD 浓度显著低于无 UTI 女性患者（p<0.01）。而男性患者的血清 25OHD 水平与 UTI 之间无关联（p>0.05）。多变量逻辑回归模型显示，UTI 与 25OHD、女性、中性粒细胞与淋巴细胞比值和 C 反应蛋白呈显著相关（p<0.05）。
UTI 与女性患者中最显著的 25OHD 浓度降低相关。UTI 与低血清 25OHD 水平和女性之间的关联是相互独立的。
