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在巴西意外接种疫苗的女性母乳中寻找黄热病病毒疫苗

The search for yellow fever virus vaccine in breast milk of inadvertently vaccinated women in Brazil.

作者信息

Fernandes Eder Gatti, Nogueira Juliana Silva, Porto Victor Bertollo Gomes, Sato Helena Keico

机构信息

Centro de Vigilância Epidemiológica "Prof. Alexandre Vranjac", Coordenadoria de Controle de Doenças, Secretaria de Estado da Saúde, São Paulo, São Paulo, Brazil.

Núcleo de Doenças de Transmissão Vetorial, Instituto Adolfo Lutz, São Paulo, São Paulo, Brazil.

出版信息

Rev Inst Med Trop Sao Paulo. 2020;62:e33. doi: 10.1590/s1678-9946202062033. Epub 2020 May 29.

Abstract

Eleven lactating women were inadvertently vaccinated with 17DD yellow fever vaccine in a small city of Sao Paulo State, Brazil. Their infants were being exclusively breast-fed and the breastfeeding was interrupted for 10 days. Serum and breastmilk were collected from the vaccinated mothers and tested for the presence of genomic RNA of the vaccine strain 8, 10 and 15 days after vaccination. Viral RNA was not detected in any of the serum and human milk samples tested and the infants remained asymptomatic. Our result strengthens the effectineness of stopping breastfeeding for 10 days after the inadvertent yellow fever vaccination of lactating women.

摘要

在巴西圣保罗州的一个小城市,11名哺乳期妇女意外接种了17DD黄热病疫苗。她们的婴儿一直纯母乳喂养,母乳喂养因此中断了10天。在接种疫苗后的第8、10和15天,采集了接种疫苗母亲的血清和母乳,检测疫苗株基因组RNA的存在情况。在所检测的任何血清和母乳样本中均未检测到病毒RNA,婴儿也一直无症状。我们的结果强化了哺乳期妇女意外接种黄热病疫苗后停止母乳喂养10天的有效性。

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Breastfeeding and the use of human milk.母乳喂养与人类乳汁使用。
Pediatrics. 2012 Mar;129(3):e827-41. doi: 10.1542/peds.2011-3552. Epub 2012 Feb 27.

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