Department of Internal Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, Connecticut, USA
Department of Internal Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, Connecticut, USA.
BMJ Case Rep. 2021 Feb 4;14(2):e240531. doi: 10.1136/bcr-2020-240531.
We present a case of a patient who had a history of severe coronavirus disease (COVID-19) 4 months prior to this current presentation and, after a long asymptomatic period, subsequently tested positive for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) by a RNA PCR assay, after several interval negative SARS-CoV-2 RNA tests. We present this potential case of SARS-CoV-2 reinfection in order to incite discussion around differentiating persistent infection with intermittent viral shedding and reinfection, as well as to discuss evolving knowledge and approaches to the clinical management, follow-up molecular testing and treatment of COVID-19 reinfection.
我们报告了 1 例病例，该患者在此次就诊前 4 个月患有严重的冠状病毒病（COVID-19），在长时间无症状期后，多次间隔性 SARS-CoV-2 RNA 检测阴性后，通过 RNA PCR 检测呈严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）阳性。我们提出了这种潜在的 SARS-CoV-2 再感染的情况，目的是引发关于持续感染伴间歇性病毒脱落与再感染的区别的讨论，并讨论关于 COVID-19 再感染的临床管理、随访分子检测和治疗的不断发展的知识和方法。
