Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
J Med Virol. 2020 Dec;92(12):3807-3814. doi: 10.1002/jmv.26130. Epub 2020 Jun 19.
This study aimed to evaluate the incidence of and factors associated with persistence and clearance of oral human papillomavirus (HPV) infections.
A prospective cohort study invited 458 subjects (231 HPV-positive and 227 HPV-negative at baseline) to attend follow-ups at 12 months. Those 231 HPV-positive subjects and 10 new infections were invited to reassessment at 24 months. We used next-gen sequencing for detection and genotyping of HPV.
α-HPV infections showed higher persistence rates than β/γ-HPV (22.7% vs 9.2% at 12 months [P < .05], 10.6% vs 6.8% at 24 months [P = .30]). Clearance rates of α-HPV were lower than β/γ-HPV at 12 months (31.8% vs 45.1%; P = .05) and higher at 24 months (7.6% vs 4.8%; P = .36). Persistence of β/γ-HPV was positively associated with males (crude odds ratio [COR] = 3.8, 95% confidence interval [CI] = 1.3-11.2), elderly (51-65 vs 16-50 years; COR = 5.1, 95% CI = 1.2-22.3), and smoking (COR = 4.3, 95% CI = 1.9-9.6). Drinking (COR = 0.5, 95% CI = 0.3-0.9), handwashing less than 90% of times before meals (COR = 0.6, 95% CI = 0.3-0.9), and using public bath more than once per month (COR = 0.5, 95% CI = 0.2-0.9) were risk factors hindering β/γ-HPV clearance.
This study identified factors associated with persistence and clearance of oral HPV infections among Chinese. Studies on other ethnogeographic groups may further inform prevention strategies of oral HPV infection and immunization programmes.
本研究旨在评估口腔人乳头瘤病毒（HPV）感染的持续存在和清除率及其相关因素。
一项前瞻性队列研究邀请了 458 名受试者（基线时 231 名 HPV 阳性和 227 名 HPV 阴性）参加 12 个月的随访。231 名 HPV 阳性受试者和 10 例新感染患者受邀在 24 个月时进行重新评估。我们使用下一代测序检测和 HPV 基因分型。
α-HPV 感染的持续存在率高于β/γ-HPV（12 个月时分别为 22.7%和 9.2%[P<0.05]，24 个月时分别为 10.6%和 6.8%[P=0.30]）。α-HPV 的清除率在 12 个月时低于β/γ-HPV（31.8%比 45.1%；P=0.05），在 24 个月时高于β/γ-HPV（7.6%比 4.8%；P=0.36）。β/γ-HPV 的持续存在与男性（未经校正优势比 [COR] = 3.8，95%置信区间 [CI] = 1.3-11.2）、老年（51-65 岁比 16-50 岁；COR = 5.1，95%CI = 1.2-22.3）和吸烟（COR = 4.3，95%CI = 1.9-9.6）有关。饮酒（COR = 0.5，95%CI = 0.3-0.9）、饭前洗手次数少于 90%（COR = 0.6，95%CI = 0.3-0.9）和每月使用公共浴室超过一次（COR = 0.5，95%CI = 0.2-0.9）是阻碍β/γ-HPV 清除的危险因素。
本研究确定了与中国人口腔 HPV 感染持续存在和清除相关的因素。针对其他种族地理群体的研究可能会进一步为口腔 HPV 感染的预防策略和免疫接种方案提供信息。
