Key Lab of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Wushan Rd-381, Guangzhou 510641, People's Republic of China.
Org Lett. 2020 Jun 19;22(12):4781-4785. doi: 10.1021/acs.orglett.0c01580. Epub 2020 Jun 3.
Herein, we present a ruthenium-catalyzed new hydrogen evolution -aminoalkylation of phenolic derivatives with cyclic amines as the coupling agents. The developed cross-coupling reaction offers a practical platform for direct access to a variety of functionalized phenols with the features of good substrate and functional group compatibility, readily available catalyst system and feedstocks, no need for additional sacrificial oxidants, and high atom efficiency.
在此，我们提出了一种钌催化的新型氢转移 - 芳基化反应，使用环状胺作为偶联试剂，与酚衍生物进行反应。所开发的交叉偶联反应为直接合成各种功能化酚类化合物提供了一个实用的平台，具有良好的底物和官能团兼容性、易得的催化剂体系和原料、无需额外的牺牲氧化剂以及高原子经济性等特点。
