• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Sirtuin-1 和血管内皮生长因子表达与脂肪肉瘤肿瘤进展和预后不良的相关性。

Association of sirtuin-1 and vascular endothelial growth factor expression with tumor progression and poor prognosis in liposarcoma.

机构信息

Department of Orthopedics, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, P. R. China.

Department of Gynecology, Hebei Medical University Second Affiliated Hospital, Shijiazhuang, Hebei, P. R. China.

出版信息

J Int Med Res. 2020 Jun;48(6):300060520926355. doi: 10.1177/0300060520926355.

DOI:10.1177/0300060520926355
PMID:32493092
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7273778/
Abstract

OBJECTIVES

A relationship exists between sirtuin-1 expression and growth and survival of malignant tumors. This study aimed to investigate the prognostic value of sirtuin-1 and vascular endothelial growth factor (VEGF) expression in patients with liposarcoma by examining associations between their expression levels and clinical outcomes.

METHODS

Clinical and histopathological characteristics and follow-up and survival information were retrospectively reviewed for 42 liposarcoma cases. Sirtuin-1 and VEGF protein expression levels were evaluated by immunohistochemistry and their associations with clinical parameters were analyzed using the Spearman-rho test. Univariate and multivariate Cox regression analyses were performed to identify potential prognostic factors. Kaplan-Meier analysis was performed to analyze overall survival.

RESULTS

Sirtuin-1 and VEGF protein expression levels were significantly associated with histological grade, metastasis, and American Joint Committee on Cancer stage. A significant positive correlation was observed between sirtuin-1 and VEGF expression levels (R = 0.677). In univariate analysis, sirtuin-1 and VEGF expression were correlated with shorter overall survival, but the association was significant only for sirtuin-1 (hazard ratio = 3.752, 95% confidence interval 1.553-9.062) in multivariate analysis.

CONCLUSION

Sirtuin-1 and VEGF expression levels are significantly correlated with progression of liposarcoma, and sirtuin-1 expression significantly predicts a poor prognosis in patients with liposarcoma.

摘要

目的

Sirtuin-1 的表达与恶性肿瘤的生长和存活之间存在关联。本研究旨在通过检测 Sirtuin-1 和血管内皮生长因子（VEGF）表达水平与临床结局之间的关系，来探讨其在脂肪肉瘤患者中的预后价值。

方法

回顾性分析了 42 例脂肪肉瘤患者的临床和组织病理学特征以及随访和生存信息。采用免疫组织化学法检测 Sirtuin-1 和 VEGF 蛋白表达水平，并采用 Spearman-rho 检验分析其与临床参数的相关性。采用单因素和多因素 Cox 回归分析来确定潜在的预后因素。采用 Kaplan-Meier 分析来分析总生存期。

结果

Sirtuin-1 和 VEGF 蛋白表达水平与组织学分级、转移和美国癌症联合委员会分期显著相关。Sirtuin-1 和 VEGF 表达水平之间存在显著的正相关（R=0.677）。单因素分析显示，Sirtuin-1 和 VEGF 表达与总生存期缩短相关，但多因素分析仅显示 Sirtuin-1 与总生存期相关（危险比=3.752，95%置信区间 1.553-9.062）。

结论

Sirtuin-1 和 VEGF 表达水平与脂肪肉瘤的进展显著相关，Sirtuin-1 表达水平显著预测脂肪肉瘤患者的预后不良。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb8c/7273778/4c94b6303111/10.1177_0300060520926355-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb8c/7273778/ad232c9cc788/10.1177_0300060520926355-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb8c/7273778/4c94b6303111/10.1177_0300060520926355-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb8c/7273778/ad232c9cc788/10.1177_0300060520926355-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb8c/7273778/4c94b6303111/10.1177_0300060520926355-fig2.jpg

相似文献

1
Association of sirtuin-1 and vascular endothelial growth factor expression with tumor progression and poor prognosis in liposarcoma.Sirtuin-1 和血管内皮生长因子表达与脂肪肉瘤肿瘤进展和预后不良的相关性。
J Int Med Res. 2020 Jun;48(6):300060520926355. doi: 10.1177/0300060520926355.
2
Correlation of vascular endothelial growth factor expression with tumor recurrence and poor prognosis in patients with pN0 gastric cancer.血管内皮生长因子表达与 pN0 期胃癌患者肿瘤复发和预后不良的相关性。
World J Surg. 2012 Jan;36(1):109-17. doi: 10.1007/s00268-011-1192-6.
3
Prognostic implications of the immunohistochemical expression of perilipin 1 and adipophilin in high-grade liposarcoma.高危脂肪肉瘤中 perilipin 1 和 adipophilin 的免疫组织化学表达的预后意义。
J Clin Pathol. 2024 Sep 19;77(10):676-682. doi: 10.1136/jcp-2023-208814.
4
H3K27me3 and VEGF is associated with poor prognosis in patients with synovial sarcoma.H3K27me3和血管内皮生长因子（VEGF）与滑膜肉瘤患者的不良预后相关。
Pathol Res Pract. 2018 Jul;214(7):974-977. doi: 10.1016/j.prp.2018.05.015. Epub 2018 May 20.
5
Clinical and prognostic significance of OPN and VEGF expression in patients with non-small-cell lung cancer.骨桥蛋白和血管内皮生长因子在非小细胞肺癌患者中的表达及其临床和预后意义
Cancer Epidemiol. 2015 Aug;39(4):539-44. doi: 10.1016/j.canep.2015.05.010. Epub 2015 Jun 27.
6
Overexpression of Sirtuin-1 is associated with poor clinical outcome in esophageal squamous cell carcinoma.沉默调节蛋白1的过表达与食管鳞状细胞癌的不良临床预后相关。
Tumour Biol. 2016 Jun;37(6):7139-48. doi: 10.1007/s13277-015-4459-y. Epub 2015 Dec 12.
7
SDF-1 Expression is Associated with Poor Prognosis in Osteosarcoma.基质细胞衍生因子-1的表达与骨肉瘤的不良预后相关。
Ann Clin Lab Sci. 2016 Sep;46(5):508-14.
8
Differential expression of vascular endothelial growth factor A, its receptors VEGFR-1, -2, and -3 and co-receptors neuropilin-1 and -2 does not predict bevacizumab response in human astrocytomas.血管内皮生长因子A、其受体VEGFR-1、-2和-3以及共受体神经纤毛蛋白-1和-2的差异表达不能预测人星形细胞瘤中贝伐单抗的反应。
Neuro Oncol. 2016 Feb;18(2):173-83. doi: 10.1093/neuonc/nov288. Epub 2015 Nov 30.
9
Expression of Leptin and Sirtuin-1 is associated with poor prognosis in patients with osteosarcoma.瘦素和沉默调节蛋白1的表达与骨肉瘤患者的不良预后相关。
Pathol Res Pract. 2016 Apr;212(4):319-24. doi: 10.1016/j.prp.2016.02.002. Epub 2016 Feb 4.
10
The clinical significance of vascular endothelial growth factor in malignant ascites.血管内皮生长因子在恶性腹水中的临床意义
Tumour Biol. 2016 Mar;37(3):3719-25. doi: 10.1007/s13277-015-4198-0. Epub 2015 Oct 13.

引用本文的文献

1
Deciphering the prognostic and therapeutic significance of BAG1 and BAG2 for predicting distinct survival outcome and effects on liposarcoma.解析 BAG1 和 BAG2 对预测不同生存结局和脂肪肉瘤治疗效果的预后及治疗意义。
Sci Rep. 2024 Oct 4;14(1):23084. doi: 10.1038/s41598-024-67659-6.
2
The potential value of the Purinergic pathway in the prognostic assessment and clinical application of kidney renal clear cell carcinoma.嘌呤能通路在肾透明细胞癌预后评估和临床应用中的潜在价值。
Aging (Albany NY). 2024 Jan 4;16(1):246-266. doi: 10.18632/aging.205364.
3
EGFR, VEGF, and angiogenesis promote the development of lipoma in the oral cavity.

本文引用的文献

1
SIRT1 Expression Is Associated With Cell Proliferation in Angiosarcoma.SIRT1表达与血管肉瘤中的细胞增殖相关。
Anticancer Res. 2019 Mar;39(3):1143-1150. doi: 10.21873/anticanres.13223.
2
Chromatin accessibility changes are associated with enhanced growth and liver metastasis capacity of acid-adapted colorectal cancer cells.染色质可及性的改变与酸性适应的结直肠癌细胞生长和肝转移能力的增强有关。
Cell Cycle. 2019 Feb;18(4):511-522. doi: 10.1080/15384101.2019.1578145. Epub 2019 Feb 11.
3
Sirtuin 1 genetic variation, energy balance and colorectal cancer risk by sex and subsite in the Netherlands Cohort Study.
表皮生长因子受体（EGFR）、血管内皮生长因子（VEGF）和血管生成促进口腔脂肪瘤的发展。
Braz Dent J. 2023 Mar-Apr;34(2):113-121. doi: 10.1590/0103-6440202305117.
4
Deciphering the Prognostic and Therapeutic Significance of Cell Cycle Regulator CENPF: A Potential Biomarker of Prognosis and Immune Microenvironment for Patients with Liposarcoma.解析细胞周期调控因子 CENPF 的预后和治疗意义：脂肪肉瘤患者预后和免疫微环境的潜在生物标志物。
Int J Mol Sci. 2023 Apr 10;24(8):7010. doi: 10.3390/ijms24087010.
5
Role of Sirtuins in Diabetes and Age-Related Processes.沉默调节蛋白在糖尿病及与年龄相关过程中的作用。
Cureus. 2022 Sep 4;14(9):e28774. doi: 10.7759/cureus.28774. eCollection 2022 Sep.
6
Comprehensive Analysis of 5-Methylcytosine Profiles of Messenger RNA in Human High-Grade Serous Ovarian Cancer by MeRIP Sequencing.通过MeRIP测序对人高级别浆液性卵巢癌中信使核糖核酸的5-甲基胞嘧啶谱进行综合分析。
Cancer Manag Res. 2021 Aug 3;13:6005-6018. doi: 10.2147/CMAR.S319312. eCollection 2021.
Sirtuin 1 基因变异、能量平衡与荷兰队列研究中按性别和部位划分的结直肠癌风险。
Sci Rep. 2018 Nov 8;8(1):16540. doi: 10.1038/s41598-018-34728-6.
4
SIRT1 in Secretory Organ Cancer.分泌器官癌症中的SIRT1
Front Endocrinol (Lausanne). 2018 Sep 24;9:569. doi: 10.3389/fendo.2018.00569. eCollection 2018.
5
SIRT1 and Estrogen Signaling Cooperation for Breast Cancer Onset and Progression.SIRT1与雌激素信号传导在乳腺癌发生和进展中的协同作用
Front Endocrinol (Lausanne). 2018 Sep 27;9:552. doi: 10.3389/fendo.2018.00552. eCollection 2018.
6
Effect of Sirtuin 1 inhibition on matrix metalloproteinase 2 and Forkhead box O3a expression in breast cancer cells.沉默调节蛋白1抑制对乳腺癌细胞中基质金属蛋白酶2和叉头框蛋白O3a表达的影响。
Genes Dis. 2017 Nov 8;4(4):240-246. doi: 10.1016/j.gendis.2017.11.001. eCollection 2017 Dec.
7
H3K27me3 and VEGF is associated with poor prognosis in patients with synovial sarcoma.H3K27me3和血管内皮生长因子（VEGF）与滑膜肉瘤患者的不良预后相关。
Pathol Res Pract. 2018 Jul;214(7):974-977. doi: 10.1016/j.prp.2018.05.015. Epub 2018 May 20.
8
Clinicopathological and predictive significance of SIRT1 and peroxisome proliferator-activated receptor gamma in esophageal squamous cell carcinoma: The correlation with EGFR and Survivin.SIRT1和过氧化物酶体增殖物激活受体γ在食管鳞状细胞癌中的临床病理及预测意义：与表皮生长因子受体和生存素的相关性
Pathol Res Pract. 2018 May;214(5):686-690. doi: 10.1016/j.prp.2018.03.018. Epub 2018 Mar 22.
9
MicroRNA-638 inhibits cell growth and tubule formation by suppressing VEGFA expression in human Ewing sarcoma cells.微小 RNA-638 通过抑制人尤文肉瘤细胞中 VEGFA 的表达来抑制细胞生长和管腔形成。
Biosci Rep. 2018 Jan 19;38(1). doi: 10.1042/BSR20171017. Print 2018 Feb 28.
10
Vascular endothelial growth factor gene polymorphisms and gastric cancer risk: a meta-analysis.血管内皮生长因子基因多态性与胃癌风险：一项荟萃分析。
J BUON. 2017 May-Jun;22(3):714-724.