Laboratorio de Fisio-patología OváricaCentro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina.
División de Endocrinología, Hospital Carlos Durand, Buenos Aires, Argentina.
Gynecol Endocrinol. 2020 Dec;36(12):1057-1061. doi: 10.1080/09513590.2020.1769061. Epub 2020 Jun 4.
To assess serum chemerin levels and investigate the association of chemerin with the hyperandrogenic and normoandrogenic phenotypes of Polycystic Ovary Syndrome (PCOS) and with the metabolic status of the analyzed population.
A cross-sectional study was conducted on 106 women with PCOS and 60 healthy controls from Argentina. Patients were classified as showing a hyperandrogenic or normoandrogenic phenotype. Participants underwent anthropometric and clinical evaluation and markers of cardiovascular risk, insulin resistance, metabolic syndrome (MS), and serum chemerin levels were assessed.
PCOS patients showed increased levels of chemerin. In adjusted models for age and body mass index (BMI), chemerin was associated with markers of metabolic status. The analysis of chemerin levels considering the cutoff values of BMI, homeostatic model of insulin sensitivity (HOMA-IR) and TG/HDL marker showed that PCOS patients always presented higher levels of chemerin than controls. PCOS group showed increased chemerin levels independently of the presence of MS.
PCOS patients always showed increased levels of chemerin independently of their phenotype and presence of overweight, as well as higher levels of chemerin than controls when considering the cutoff values of HOMA-IR and TG/HDL. Therefore, argentine women with PCOS display increased chemerin levels independently of their metabolic or androgenic status.
评估血清趋化素水平，并探讨趋化素与多囊卵巢综合征（PCOS）的高雄激素和正常高雄激素表型以及分析人群的代谢状态之间的关系。
对来自阿根廷的 106 名 PCOS 患者和 60 名健康对照者进行了横断面研究。患者被分为高雄激素或正常高雄激素表型。参与者接受了人体测量学和临床评估，并评估了心血管风险标志物、胰岛素抵抗、代谢综合征（MS）和血清趋化素水平。
PCOS 患者的趋化素水平升高。在调整年龄和体重指数（BMI）的模型中，趋化素与代谢状态标志物相关。考虑 BMI、胰岛素抵抗稳态模型（HOMA-IR）和 TG/HDL 标志物的截断值分析趋化素水平显示，PCOS 患者的趋化素水平始终高于对照组。PCOS 组独立于 MS 的存在表现出趋化素水平升高。
PCOS 患者的趋化素水平始终升高，与他们的表型和超重无关，并且当考虑 HOMA-IR 和 TG/HDL 的截断值时，PCOS 患者的趋化素水平高于对照组。因此，阿根廷的 PCOS 女性表现出趋化素水平升高，与代谢或雄激素状态无关。
