Wang LiQiong, Zhong Yan, Ding YiLing, Shi XiaoBo, Huang Jian, Zhu FuFan
Department of Obstetrics and Gynecology, The Second XiangYa Hospital of Central South University , Hunan , China.
Gynecol Endocrinol. 2014 Oct;30(10):746-50. doi: 10.3109/09513590.2014.928687. Epub 2014 Jun 13.
To compare serum chemerin levels between women with classic hyperandrogenic PCOS, euandrogenic PCOS and matched control subjects.
This study was carried out at the Second XiangYa Hospital between July 2012 and April 2013. Sixty-seven women with PCOS and 20 controls were included. Blood pressure, body mass index (BMI), waist to hip ratio (WHR), fasting insulin, fasting plasma glucose and blood serum hormone and blood lipid were measured. Transvaginal ultrasound was performed. Serum chemerin was measured by ELISA.
Serum chemerin was significantly higher in classic hyperandrogenic PCOS compared with euandrogenic PCOS and controls (311.07 ± 141.87 ng/mL versus 228.03 ± 119.66 ng/mL and 225.87 ± 86.44 ng/mL, p < 0.05). Serum chemerin was positively related to follicle count, ovarian volume, the level of testosterone, luteinizing hormone/follicle-stimulating hormone, low-density lipoprotein, triglycerides, fasting blood insulin, insulin resistance by homeostasis model assessment, WHR and BMI, while negatively related to the level of high-density lipoprotein. Multiple linear regression analyses revealed ovarian volumes and WHR were the significant influencing factors of chemerin (p < 0.05). The area under the receiver operating characteristic curve for chemerin reached a value of 0.684 (0.572-0.796, 95% confidence interval). The best compromise between sensitivity (80.0%) and specificity (47.6%) was obtained with a cutoff value of 200.94 ng/mL.
Serum chemerin level was increased in Chinese women with classic hyperandrogenic PCOS. Serum chemerin measurement offers a relatively moderate diagnostic potency with a sensitivity of 80.0% and a specificity of 47.6% at 200.94 ng/mL. This suggested that chemerin may be involved in the development of the metabolic syndrome of classic PCOS.
比较经典高雄激素性多囊卵巢综合征（PCOS）女性、正常雄激素性PCOS女性与匹配的对照受试者之间的血清chemerin水平。
本研究于2012年7月至2013年4月在中南大学湘雅二医院进行。纳入67例PCOS女性和20例对照。测量血压、体重指数（BMI）、腰臀比（WHR）、空腹胰岛素、空腹血糖、血清激素和血脂。进行经阴道超声检查。采用酶联免疫吸附测定法（ELISA）检测血清chemerin。
经典高雄激素性PCOS患者的血清chemerin水平显著高于正常雄激素性PCOS患者和对照（311.07±141.87 ng/mL对228.03±119.66 ng/mL和225.87±86.44 ng/mL，p<0.05）。血清chemerin与卵泡计数、卵巢体积、睾酮水平、黄体生成素/卵泡刺激素、低密度脂蛋白、甘油三酯、空腹血胰岛素、稳态模型评估的胰岛素抵抗、WHR和BMI呈正相关，而与高密度脂蛋白水平呈负相关。多元线性回归分析显示卵巢体积和WHR是chemerin的显著影响因素（p<0.05）。chemerin的受试者工作特征曲线下面积达到0.684（0.572 - 0.796，95%置信区间）。截断值为200.94 ng/mL时，敏感性（80.0%）和特异性（47.6%）之间达到最佳折衷。
中国经典高雄激素性PCOS女性的血清chemerin水平升高。血清chemerin检测具有相对中等的诊断效能，在200.94 ng/mL时敏感性为80.0%，特异性为47.6%。这表明chemerin可能参与经典PCOS代谢综合征的发生发展。
