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In silico veritas? Potential limitations for SARS-CoV-2 vaccine development based on T-cell epitope prediction.

作者信息

Silva-Arrieta Sandra, Goulder Philip J R, Brander Christian

机构信息

IrsiCaixa AIDS Research Institute, Hospital Germans Trias i Pujol, Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain.

Department of Paediatrics, University of Oxford, Oxford, United Kingdom.

出版信息

PLoS Pathog. 2020 Jun 4;16(6):e1008607. doi: 10.1371/journal.ppat.1008607. eCollection 2020 Jun.

DOI:10.1371/journal.ppat.1008607
PMID:32497149
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7272002/
Abstract
摘要

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本文引用的文献

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Clinical and immunological features of severe and moderate coronavirus disease 2019.新型冠状病毒病 2019 重症和中度患者的临床和免疫学特征。
J Clin Invest. 2020 May 1;130(5):2620-2629. doi: 10.1172/JCI137244.
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Protective versus pathologic pre-exposure cytokine profiles in dengue virus infection.登革热病毒感染中的保护性前暴露细胞因子特征与病理性前暴露细胞因子特征。
PLoS Negl Trop Dis. 2018 Dec 17;12(12):e0006975. doi: 10.1371/journal.pntd.0006975. eCollection 2018 Dec.
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Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding.病原体衍生的 HLA-E 结合表位揭示了广泛的主要锚定口袋耐受性和构象可变形的肽结合。
Nat Commun. 2018 Aug 7;9(1):3137. doi: 10.1038/s41467-018-05459-z.
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Alternative effector-function profiling identifies broad HIV-specific T-cell responses in highly HIV-exposed individuals who remain uninfected.替代性效应功能分析揭示了在长期高暴露于HIV但未感染个体中广泛的HIV特异性T细胞反应。
J Infect Dis. 2015 Mar 15;211(6):936-46. doi: 10.1093/infdis/jiu534. Epub 2014 Sep 23.
5
Direct interrogation of viral peptides presented by the class I HLA of HIV-infected T cells.对HIV感染的T细胞的I类人白细胞抗原(HLA)所呈递的病毒肽进行直接询问。
J Virol. 2014 Nov;88(22):12992-3004. doi: 10.1128/JVI.01914-14. Epub 2014 Aug 27.
6
HLA class I supertypes: a revised and updated classification.HLA I类超型:修订与更新后的分类
BMC Immunol. 2008 Jan 22;9:1. doi: 10.1186/1471-2172-9-1.
7
Extensive HLA class I allele promiscuity among viral CTL epitopes.病毒CTL表位中广泛存在的HLA I类等位基因混杂现象。
Eur J Immunol. 2007 Sep;37(9):2419-33. doi: 10.1002/eji.200737365.
8
Have we cut ourselves too short in mapping CTL epitopes?在绘制细胞毒性T淋巴细胞(CTL)表位图谱时,我们是否做得过于简略了?
Trends Immunol. 2006 Jan;27(1):11-6. doi: 10.1016/j.it.2005.11.001. Epub 2005 Nov 16.
9
HLA-B57-restricted cytotoxic T-lymphocyte activity in a single infected subject toward two optimal epitopes, one of which is entirely contained within the other.单个感染个体中针对两个最佳表位的HLA - B57限制性细胞毒性T淋巴细胞活性,其中一个表位完全包含在另一个表位内。
J Virol. 2000 Jun;74(11):5291-9. doi: 10.1128/jvi.74.11.5291-5299.2000.
10
Epstein-Barr virus in nasal lymphomas contains multiple ongoing mutations in the EBNA-1 gene.鼻淋巴瘤中的爱泼斯坦-巴尔病毒在EBNA-1基因中存在多个正在发生的突变。
Blood. 1998 Jul 15;92(2):600-6.