Brunner Maximilian, Belyaev Orlin, Bösch Florian, Müller-Debus Charlotte Friederieke, Radulova-Mauersberger Olga, Wellner Ulrich Friedrich, Keck Tobias, Uhl Waldemar, Werner Jens, Witzigmann Helmut, Grützmann Robert
Klinik für Allgemein- und Viszeralchirurgie, Universitätsklinikum Erlangen, Deutschland.
Klinik für Allgemein- und Viszeralchirurgie, Universitätsklinikum St. Josef-Hospital Bochum, Deutschland.
Zentralbl Chir. 2020 Aug;145(4):344-353. doi: 10.1055/a-1158-9536. Epub 2020 Jun 4.
A steady improvement in modern imaging as well as increasing age in society have led to an increasing number of cystic pancreatic tumours being detected. Pancreatic cysts are a clinically challenging entity because they span a broad biological spectrum and their differentiation is often difficult, especially in small tumours. Therefore, they require a differentiated indication for indication of surgery. To determine recommendations for the surgical indication in cystic tumours of the pancreas, a quality committee for pancreatic diseases of the German Society for General and Visceral Surgery performed a systematic literature search and created this review. Based on the current evidence, signs of malignancy and high-risk criteria (icterus due to cystic pancreatic duct obstruction in the bile duct, enhancing mural nodules ≥ 5 mm or solid components in the cyst or pancreatic duct ≥ 10 mm), as well as symptoms, are a surgical indication, independently of the cyst entity (except pseudocysts). If the entity of the pancreatic cyst is detectable by diagnostic imaging, all main duct IPMN and IPMN of the mixed type, all MCN > 4 cm and all SPN should be resected. SCN and branch-duct IPMN without worrisome features do not constitute an indication for surgery. The indication of operation in branch-duct IPMN with relative risk criteria and MCN < 4 cm is the subject of current discussions and should be individualised. By defining indication recommendations, the present work aims to improve the indication quality in cystic pancreatic tumours. However, the surgical indication should always be individualised, taking into account age, comorbidities and the patient's wishes.
现代成像技术的不断进步以及社会人口老龄化,导致胰腺囊性肿瘤的检出数量不断增加。胰腺囊肿是一种临床难题,因为它们具有广泛的生物学谱,其鉴别往往困难,尤其是在小肿瘤中。因此,它们需要有区别的手术指征。为了确定胰腺囊性肿瘤手术指征的建议,德国普通和内脏外科学会胰腺疾病质量委员会进行了系统的文献检索并撰写了本综述。根据目前的证据,恶性征象和高风险标准(因胆管内胰腺囊肿性导管梗阻导致黄疸、增强的壁结节≥5mm或囊肿或胰腺导管内实性成分≥10mm)以及症状,是手术指征,与囊肿类型无关(假性囊肿除外)。如果胰腺囊肿的类型可通过诊断性成像检测到,所有主胰管内乳头状黏液性肿瘤(IPMN)和混合型IPMN、所有直径>4cm的黏液性囊性肿瘤(MCN)以及所有实性假乳头状瘤(SPN)均应切除。无可疑特征的浆液性囊性肿瘤(SCN)和分支胰管IPMN不构成手术指征。具有相对风险标准且直径<4cm的分支胰管IPMN的手术指征是当前讨论的主题,应个体化。通过定义指征建议,本研究旨在提高胰腺囊性肿瘤的指征质量。然而,手术指征应始终个体化,同时考虑年龄、合并症和患者意愿。