与生物膜形成相关的葡萄球菌疫苗抗原。
Staphylococcal Vaccine Antigens related to biofilm formation.
作者信息
Mirzaei Bahman, Babaei Ryhaneh, Valinejad Sina
机构信息
Department of Medical Microbiology and Virology, Faculty of Medicine, Mazandaran University of Medical Sciences , Sari, Iran.
Department of Medical Microbiology and Virology, School of Medicine, Zanjan University of Medical Science , Zanjan, Iran.
出版信息
Hum Vaccin Immunother. 2021 Jan 2;17(1):293-303. doi: 10.1080/21645515.2020.1767449. Epub 2020 Jun 4.
Abstract
The number and frequency of multidrug-resistant (MDR) strains as a frequent cause of nosocomial infections have increased, especially for , in part due to device-related infections. The transition to antibiotic-resistance in related bacterial genes and the capability for immune escape have increased the sustainability of biofilms produced by these bacteria. The formation and changes in biofilms have been suggested as a target to prevent or treat staphylococcal infections. Thus, this study reviews the development of candidate staphylococcal vaccines by database searching, and evaluates the immunogenicity and efficacy profiles of bacterial components involved in biofilms. The literature suggests that using common staphylococcal vaccine antigens and multivalent vaccines should further enhance vaccine efficacy.
摘要
作为医院感染常见病因的多重耐药（MDR）菌株的数量和频率有所增加，尤其是对于与器械相关的感染而言，部分原因就在于此。相关细菌基因向抗生素耐药性的转变以及免疫逃逸能力提高了这些细菌产生的生物膜的可持续性。生物膜的形成和变化已被认为是预防或治疗葡萄球菌感染的一个靶点。因此，本研究通过数据库检索回顾了候选葡萄球菌疫苗的发展情况，并评估了生物膜中细菌成分的免疫原性和功效概况。文献表明，使用常见的葡萄球菌疫苗抗原和多价疫苗应能进一步提高疫苗效力。
相似文献
1
Staphylococcal Vaccine Antigens related to biofilm formation.与生物膜形成相关的葡萄球菌疫苗抗原。
Hum Vaccin Immunother. 2021 Jan 2;17(1):293-303. doi: 10.1080/21645515.2020.1767449. Epub 2020 Jun 4.
2
Genomics of Staphylococcus aureus and Staphylococcus epidermidis from Periprosthetic Joint Infections and Correlation to Clinical Outcome.假体周围关节感染的金黄色葡萄球菌和表皮葡萄球菌的基因组学及其与临床结果的相关性。
Microbiol Spectr. 2022 Aug 31;10(4):e0218121. doi: 10.1128/spectrum.02181-21. Epub 2022 Jun 28.
3
Combination antimicrobial therapy: in vitro synergistic effect of anti-staphylococcal drug oxacillin with antimicrobial peptide nisin against Staphylococcus epidermidis clinical isolates and Staphylococcus aureus biofilms.联合抗菌治疗：抗葡萄球菌药物苯唑西林与抗菌肽乳链菌肽对表皮葡萄球菌临床分离株和金黄色葡萄球菌生物膜的体外协同作用。
Ann Clin Microbiol Antimicrob. 2024 Jan 20;23(1):7. doi: 10.1186/s12941-024-00667-6.
4
Immunoprophylaxis and immunotherapy of Staphylococcus epidermidis infections: challenges and prospects.表皮葡萄球菌感染的免疫预防和免疫治疗：挑战与展望。
Expert Rev Vaccines. 2012 Mar;11(3):319-34. doi: 10.1586/erv.11.190.
5
Antibacterial and anti-biofilm activities of thiazolidione derivatives against clinical staphylococcus strains.噻唑烷二酮衍生物对临床葡萄球菌菌株的抗菌及抗生物膜活性
Emerg Microbes Infect. 2015 Jan;4(1):e1. doi: 10.1038/emi.2015.1. Epub 2015 Jan 7.
6
Correlation Between Biofilm Formation and Antibiotic Resistance in MRSA and MSSA Isolated from Clinical Samples in Iran: A Systematic Review and Meta-Analysis.伊朗临床样本中分离的 MRSA 和 MSSA 中生物膜形成与抗生素耐药性的相关性：系统评价和荟萃分析。
Microb Drug Resist. 2020 Sep;26(9):1071-1080. doi: 10.1089/mdr.2020.0001. Epub 2020 Mar 10.
7
Role of Extracellular DNA in Dalbavancin Activity against Methicillin-Resistant Staphylococcus aureus (MRSA) Biofilms in Patients with Skin and Soft Tissue Infections.细胞外 DNA 在达巴万星治疗皮肤和软组织感染耐甲氧西林金黄色葡萄球菌（MRSA）生物膜中的作用。
Microbiol Spectr. 2022 Apr 27;10(2):e0035122. doi: 10.1128/spectrum.00351-22. Epub 2022 Apr 13.
8
Effect of Antimicrobial and Physical Treatments on Growth of Multispecies Staphylococcal Biofilms.抗菌和物理处理对多物种葡萄球菌生物膜生长的影响
Appl Environ Microbiol. 2017 May 31;83(12). doi: 10.1128/AEM.03483-16. Print 2017 Jun 15.
9
Development of a rat central venous catheter model for evaluation of vaccines to prevent Staphylococcus epidermidis and Staphylococcus aureus early biofilms.建立大鼠中心静脉导管模型以评估预防表皮葡萄球菌和金黄色葡萄球菌早期生物膜形成的疫苗。
Hum Vaccin. 2011 Jun;7(6):630-8. doi: 10.4161/hv.7.6.15407. Epub 2011 Jun 1.
10
Low levels of β-lactam antibiotics induce extracellular DNA release and biofilm formation in Staphylococcus aureus.低水平β-内酰胺类抗生素可诱导金黄色葡萄球菌释放细胞外 DNA 并形成生物膜。
mBio. 2012 Jul 31;3(4):e00198-12. doi: 10.1128/mBio.00198-12. Print 2012.
引用本文的文献
1
Characterization of proteins present in the biofilm matrix and outer membrane vesicles of during iron-sufficient and iron-restricted growth: identification of potential protective antigens through analyses.铁充足和铁限制生长期间生物膜基质和外膜囊泡中存在的蛋白质的表征：通过分析鉴定潜在的保护性抗原。
mBio. 2025 May 14;16(5):e0064425. doi: 10.1128/mbio.00644-25. Epub 2025 Apr 17.
2
Immune-based strategies for the treatment of biofilm infections.基于免疫的生物膜感染治疗策略。
Biofilm. 2025 Feb 20;9:100264. doi: 10.1016/j.bioflm.2025.100264. eCollection 2025 Jun.
3
Analysis of immunogenicity and purification methods in conjugated polysaccharide vaccines: a new approach in fighting pathogenic bacteria.结合多糖疫苗的免疫原性及纯化方法分析：对抗病原菌的新方法
Front Immunol. 2024 Nov 20;15:1483740. doi: 10.3389/fimmu.2024.1483740. eCollection 2024.
4
The pathogenicity and virulence of the opportunistic pathogen .机会致病菌的致病性和毒力。
Virulence. 2024 Dec;15(1):2359483. doi: 10.1080/21505594.2024.2359483. Epub 2024 Jun 13.
5
Antenatal tetanus, diphtheria, and acellular pertussis (Tdap) immunization and risk of serogroup 19 IPD in children: An indirect cohort study.产前破伤风、白喉和无细胞百日咳（Tdap）免疫接种与儿童血清群 19 侵袭性疾病的风险：一项间接队列研究。
Hum Vaccin Immunother. 2024 Dec 31;20(1):2305522. doi: 10.1080/21645515.2024.2305522. Epub 2024 Feb 8.
6
Antibiotic resistance in patients with liver cirrhosis: Prevalence and current approach to tackle.肝硬化患者的抗生素耐药性：患病率及当前应对方法
World J Clin Cases. 2023 Nov 6;11(31):7530-7542. doi: 10.12998/wjcc.v11.i31.7530.
7
The frequency of adherence, biofilm-associated, Arginine Catabolic Mobile element genes, and biofilm formation in clinical and healthcare worker coagulase-negative staphylococci isolates.临床和医护人员凝固酶阴性葡萄球菌分离株的黏附频率、生物膜相关、精氨酸分解移动元件基因和生物膜形成。
BMC Microbiol. 2023 Aug 15;23(1):222. doi: 10.1186/s12866-023-02959-x.
8
Molecular Epidemiology of in a Tertiary Hospital in Anhui, China: ST59 Remains a Serious Threat.中国安徽某三级医院的分子流行病学：ST59 仍然是一个严重威胁。
Infect Drug Resist. 2023 Feb 16;16:961-976. doi: 10.2147/IDR.S395220. eCollection 2023.
9
Toward an effective Staphylococcus vaccine: why have candidates failed and what is the next step?迈向有效的葡萄球菌疫苗：候选疫苗为何失败以及下一步是什么？
Expert Rev Vaccines. 2023 Jan-Dec;22(1):207-209. doi: 10.1080/14760584.2023.2179486.
10
Genetic Diversity, Antibiotic Resistance, and Virulence Gene Features of Methicillin-Resistant Epidemics in Guiyang, Southwest China.中国西南部贵阳耐甲氧西林流行菌株的遗传多样性、抗生素耐药性及毒力基因特征
Infect Drug Resist. 2022 Dec 7;15:7189-7206. doi: 10.2147/IDR.S392434. eCollection 2022.
本文引用的文献
1
Synthesis of conjugated PIA-rSesC and immunological evaluation against biofilm-forming Staphylococcus epidermidis.PIA-rSesC 缀合物的合成及对生物膜形成表皮葡萄球菌的免疫评价。
J Med Microbiol. 2019 May;68(5):791-802. doi: 10.1099/jmm.0.000910. Epub 2019 Apr 16.
2
Ses proteins as possible targets for vaccine development against Staphylococcus epidermidis infections.表皮葡萄球菌表面蛋白作为疫苗开发的可能靶点用于预防表皮葡萄球菌感染。
J Infect. 2018 Aug;77(2):119-130. doi: 10.1016/j.jinf.2018.03.013. Epub 2018 May 9.
3
Staphylococcal biofilm gene expression on biomaterials - A methodological study.生物材料上葡萄球菌生物膜基因表达的方法学研究。
J Biomed Mater Res A. 2017 Dec;105(12):3400-3412. doi: 10.1002/jbm.a.36171. Epub 2017 Sep 26.
4
The Active Component of Aspirin, Salicylic Acid, Promotes Biofilm Formation in a PIA-dependent Manner.阿司匹林的活性成分水杨酸以依赖PIA的方式促进生物膜形成。
Front Microbiol. 2017 Jan 23;8:4. doi: 10.3389/fmicb.2017.00004. eCollection 2017.
5
A Novel MSCRAMM Subfamily in Coagulase Negative Staphylococcal Species.凝固酶阴性葡萄球菌中的一个新型微生物表面成分识别黏附分子亚家族
Front Microbiol. 2016 Apr 29;7:540. doi: 10.3389/fmicb.2016.00540. eCollection 2016.
6
Staphylococcus epidermidis Affinity for Fibrinogen-Coated Surfaces Correlates with the Abundance of the SdrG Adhesin on the Cell Surface.表皮葡萄球菌对纤维蛋白原包被表面的亲和力与细胞表面SdrG黏附素的丰度相关。
Langmuir. 2015 Apr 28;31(16):4713-21. doi: 10.1021/acs.langmuir.5b00360. Epub 2015 Apr 13.
7
Staphylococcus epidermidis serine--aspartate repeat protein G (SdrG) binds to osteoblast integrin alpha V beta 3.表皮葡萄球菌丝氨酸-天冬氨酸重复蛋白 G（SdrG）与成骨细胞整合素 αVβ3 结合。
Microbes Infect. 2015 Jun;17(6):395-401. doi: 10.1016/j.micinf.2015.02.003. Epub 2015 Mar 5.
8
Anti-lipoteichoic acid monoclonal antibody (pagibaximab) studies for the prevention of staphylococcal bloodstream infections in preterm infants.抗脂磷壁酸单克隆抗体（帕吉昔单抗）预防早产儿葡萄球菌血流感染的研究。
Expert Opin Biol Ther. 2015 Apr;15(4):595-600. doi: 10.1517/14712598.2015.1019857. Epub 2015 Mar 3.
9
Autoinducer-2 increases biofilm formation via an ica- and bhp-dependent manner in Staphylococcus epidermidis RP62A.自诱导物-2通过ica和bhp依赖性方式增加表皮葡萄球菌RP62A中的生物膜形成。
Microbes Infect. 2015 May;17(5):345-52. doi: 10.1016/j.micinf.2015.01.003. Epub 2015 Jan 28.
10
Protein-based biofilm matrices in Staphylococci.葡萄球菌中基于蛋白质的生物膜基质
Front Cell Infect Microbiol. 2014 Dec 10;4:171. doi: 10.3389/fcimb.2014.00171. eCollection 2014.
Zotero 插件