Zhang Huimin, Cao Jiaxin, He Zhien, Zong Xianchun, Sun Baolin
College of Life Science and Technology, Mudanjiang Normal University, Mudanjiang, People's Republic of China.
Department of Oncology, The First Affiliated Hospital, University of Science and Technology of China, Hefei, People's Republic of China.
Infect Drug Resist. 2023 Feb 16;16:961-976. doi: 10.2147/IDR.S395220. eCollection 2023.
This study aimed to investigate the molecular characteristics, antimicrobial resistance and hemolytic phenotype of isolated from Anhui, China.
From August 2021 to January 2022, 214 isolates were collected from the Anhui Provincial Hospital. This study identified 117 methicillin-resistant and 97 methicillin-sensitive isolates, and the detection rate of methicillin-resistant isolates was 1.8-fold higher than the average isolates reported in China (53.9% vs 30.5%). isolates share identity at five or more of the seven MLST-based housekeeping loci, referred to as the clonal complex (CC). Forty ST types were found in 214 clinical isolates, with the most extensive distribution of ST59 and ST6697 typing numbers and higher CC5 detection rates than any other clonal group. (The ST typing is the result of the MLST typing website query.) To detect the virulence of ST types of , hemolysis experiments were performed on 214 clinical isolates, and it was concluded that ST59 had a relatively robust hemolytic capacity.
Anhui isolates have unique molecular and antibiotic resistance profiles. The antibiotic resistance profile may be related to the random use of antibiotics.
本研究旨在调查从中国安徽分离出的[细菌名称未给出]的分子特征、抗菌耐药性和溶血表型。
2021年8月至2022年1月，从安徽省立医院收集了214株[细菌名称未给出]分离株。本研究鉴定出117株耐甲氧西林[细菌名称未给出]和97株对甲氧西林敏感的[细菌名称未给出]分离株，耐甲氧西林分离株的检出率比中国报道的平均分离株高出1.8倍（53.9%对30.5%）。[细菌名称未给出]分离株在基于多位点序列分型（MLST）的七个管家基因座中的五个或更多个上具有相同性，称为克隆复合体（CC）。在214株临床[细菌名称未给出]分离株中发现了40种序列型（ST），其中ST59和ST6697分型数量分布最广，CC5的检出率高于任何其他克隆组。（ST分型是MLST分型网站查询的结果。）为了检测[细菌名称未给出]ST型的毒力，对214株临床分离株进行了溶血实验，得出ST59具有相对较强的溶血能力。
安徽[细菌名称未给出]分离株具有独特的分子和抗生素耐药特征。抗生素耐药特征可能与抗生素的随意使用有关。
