Zheng Peng-Ju, Wang Jin-Sheng, Liu Gui-Fang, Zhang Shu-Hua, Zhang Yi-Ying
Department of Otolaryngology, First Affiliated Hospital of Jiamusi University.
Department of Otorhinolaryngology, Second Hospital of Jiamusi Agricultural Reclamation.
Medicine (Baltimore). 2020 Jun 5;99(23):e20557. doi: 10.1097/MD.0000000000020557.
Although previous studies have reported that levocetirizine is utilized for the treatment of children with allergic rhinitis (AR), its conclusions remain inconsistent. This study aims to evaluate the efficacy and harms of levocetirizine for children with AR.
Electronic database sources will be undertaken from the beginning to the present: MEDLINE, EMBASE, The Cochrane Library, CINAHL, ACMD, PsycINFO, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure. We will not apply any restrictions to language and publication status. We will only consider randomized controlled trials of levocetirizine for children with AR. Two authors will independently scan literature, select studies, and collect data. Study quality for each included trial will be assessed using Cochrane risk of bias tool, and statistical analysis will be conducted using RevMan 5.3 software.
This study will summarize the present evidence to systematically assess the efficacy and harms of levocetirizine for children with AR.
The findings of this study intent to adequately inform stakeholders or clinicians, as well as to help develop treatment guidelines.
INPLASY202040111.
尽管先前的研究报告称左西替利嗪用于治疗儿童过敏性鼻炎（AR），但其结论仍不一致。本研究旨在评估左西替利嗪治疗儿童AR的疗效和危害。
将检索从开始到目前的电子数据库来源：MEDLINE、EMBASE、Cochrane图书馆、CINAHL、ACMD、PsycINFO、中国生物医学文献数据库和中国知网。我们将不对语言和出版状态施加任何限制。我们将仅考虑左西替利嗪治疗儿童AR的随机对照试验。两名作者将独立筛选文献、选择研究并收集数据。将使用Cochrane偏倚风险工具评估每个纳入试验的研究质量，并使用RevMan 5.3软件进行统计分析。
本研究将总结现有证据，以系统评估左西替利嗪治疗儿童AR的疗效和危害。
本研究结果旨在为利益相关者或临床医生提供充分信息，并有助于制定治疗指南。
INPLASY202040111。
