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瘦素脂肪细胞促进伤口愈合。

Skinny Fat Cells Stimulate Wound Healing.

机构信息

Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

出版信息

Cell Stem Cell. 2020 Jun 4;26(6):801-803. doi: 10.1016/j.stem.2020.04.021.

DOI:10.1016/j.stem.2020.04.021
PMID:32502400
Abstract

In this issue of Cell Stem Cell, Shook et al. (2020) reveal that dermal adipocytes regulate skin wound repair via release of fatty acids that promote macrophage recruitment and accelerated revascularization. Furthermore, mature dermal adipocytes dedifferentiate into migratory extracellularmatrix-producing myofibroblasts.

摘要

在本期《Cell Stem Cell》杂志中,Shook 等人(2020 年)揭示了真皮脂肪细胞通过释放促进巨噬细胞募集和加速血管再生的脂肪酸来调节皮肤伤口修复。此外,成熟的真皮脂肪细胞去分化为迁移的细胞外基质产生的肌成纤维细胞。

相似文献

1
Skinny Fat Cells Stimulate Wound Healing.瘦素脂肪细胞促进伤口愈合。
Cell Stem Cell. 2020 Jun 4;26(6):801-803. doi: 10.1016/j.stem.2020.04.021.
2
Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair.真皮脂肪细胞脂解和肌成纤维细胞转化是高效皮肤修复所必需的。
Cell Stem Cell. 2020 Jun 4;26(6):880-895.e6. doi: 10.1016/j.stem.2020.03.013. Epub 2020 Apr 16.
3
Insights into the unique roles of dermal white adipose tissue (dWAT) in wound healing.深入了解真皮白色脂肪组织(dWAT)在伤口愈合中的独特作用。
Front Physiol. 2024 Feb 23;15:1346612. doi: 10.3389/fphys.2024.1346612. eCollection 2024.
4
Wound infiltrating adipocytes are not myofibroblasts.浸润性脂肪细胞不是肌成纤维细胞。
Nat Commun. 2023 May 25;14(1):3020. doi: 10.1038/s41467-023-38591-6.
5
Novel prospects for scarless wound healing: The roles of myofibroblasts and adipocytes.无瘢痕伤口愈合的新前景:肌成纤维细胞和脂肪细胞的作用。
J Cell Mol Med. 2022 Oct;26(20):5113-5121. doi: 10.1111/jcmm.17535. Epub 2022 Sep 15.
6
Dermal αSMA myofibroblasts orchestrate skin wound repair via β1 integrin and independent of type I collagen production.真皮 αSMA 肌成纤维细胞通过β1 整合素并独立于 I 型胶原产生来协调皮肤伤口修复。
EMBO J. 2022 Apr 4;41(7):e109470. doi: 10.15252/embj.2021109470. Epub 2022 Feb 25.
7
Intradermal adipocytes mediate fibroblast recruitment during skin wound healing.真皮内脂肪细胞在皮肤伤口愈合过程中募集成纤维细胞。
Development. 2013 Apr;140(7):1517-27. doi: 10.1242/dev.087593.
8
Repeal and Replace: Adipocyte Regeneration in Wound Repair.废除与替代:脂肪细胞在伤口修复中的再生。
Cell Stem Cell. 2017 Apr 6;20(4):424-426. doi: 10.1016/j.stem.2017.03.015.
9
Dermal adipose tissue has high plasticity and undergoes reversible dedifferentiation in mice.皮肤脂肪组织具有高度的可塑性,并在小鼠中经历可逆的去分化。
J Clin Invest. 2019 Dec 2;129(12):5327-5342. doi: 10.1172/JCI130239.
10
Specific disruption of Lnk in murine endothelial progenitor cells promotes dermal wound healing via enhanced vasculogenesis, activation of myofibroblasts, and suppression of inflammatory cell recruitment.小鼠内皮祖细胞中Lnk的特异性破坏通过增强血管生成、激活肌成纤维细胞和抑制炎症细胞募集来促进皮肤伤口愈合。
Stem Cell Res Ther. 2016 Oct 28;7(1):158. doi: 10.1186/s13287-016-0403-3.

引用本文的文献

1
Dermal white adipose tissue: A new modulator in wound healing and regeneration.真皮白色脂肪组织:伤口愈合与再生中的新型调节因子。
Regen Ther. 2024 Dec 5;28:115-125. doi: 10.1016/j.reth.2024.11.015. eCollection 2025 Mar.
2
Subcutaneous adipose tissue: Implications in dermatological diseases and beyond.皮下脂肪组织:对皮肤病及其他领域的影响
Allergy. 2024 Dec;79(12):3310-3325. doi: 10.1111/all.16295. Epub 2024 Aug 29.
3
Preparation of Apoptotic Extracellular Vesicles from Adipose Tissue and Their Efficacy in Promoting High-Quality Skin Wound Healing.
脂肪组织来源凋亡细胞外囊泡的制备及其促进高质量皮肤伤口愈合的功效。
Int J Nanomedicine. 2023 Jun 2;18:2923-2938. doi: 10.2147/IJN.S411819. eCollection 2023.
4
Human adipose tissue-derived small extracellular vesicles promote soft tissue repair through modulating M1-to-M2 polarization of macrophages.人脂肪组织来源的小细胞外囊泡通过调节巨噬细胞 M1 向 M2 的极化促进软组织修复。
Stem Cell Res Ther. 2023 Apr 7;14(1):67. doi: 10.1186/s13287-023-03306-7.
5
miRNome and Proteome Profiling of Human Keratinocytes and Adipose Derived Stem Cells Proposed miRNA-Mediated Regulations of Epidermal Growth Factor and Interleukin 1-Alpha.人角质形成细胞和脂肪来源干细胞的 microRNA 组和蛋白质组分析 表皮生长因子和白细胞介素 1-α的 miRNA 介导调控。
Int J Mol Sci. 2023 Mar 4;24(5):4956. doi: 10.3390/ijms24054956.
6
Expert guidance on prophylaxis and treatment of dermatologic adverse events with Tumor Treating Fields (TTFields) therapy in the thoracic region.胸部肿瘤治疗电场(TTFields)疗法所致皮肤不良事件的预防与治疗专家指导意见
Front Oncol. 2023 Jan 4;12:975473. doi: 10.3389/fonc.2022.975473. eCollection 2022.
7
Adipose-PAS interactions in the context of its localised bio-engineering potential (Review).脂肪组织与过碘酸希夫反应在其局部生物工程潜力背景下的相互作用(综述)
Biomed Rep. 2021 Aug;15(2):70. doi: 10.3892/br.2021.1446. Epub 2021 Jul 5.