Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Dana-Farber Cancer Institute, Boston, MA, USA.
Departments of Pediatrics and Oncology, Johns Hopkins University, Baltimore, MD, USA.
Lancet Oncol. 2020 Jun;21(6):e330-e336. doi: 10.1016/S1470-2045(20)30166-2.
Optimising the conduct of clinical trials for diffuse intrinsic pontine glioma involves use of consistent, objective disease assessments and standardised response criteria. The Response Assessment in Pediatric Neuro-Oncology working group, consisting of an international panel of paediatric and adult neuro-oncologists, clinicians, radiologists, radiation oncologists, and neurosurgeons, was established to address issues and unique challenges in assessing response in children with CNS tumours. A working group was formed specifically to address response assessment in children and young adults with diffuse intrinsic pontine glioma and to develop a consensus on recommendations for response assessment. Response should be assessed using MRI of brain and spine, neurological examination, and anti-inflammatory or antiangiogenic drugs. Clinical imaging standards are defined. As with previous consensus recommendations, these recommendations will need to be validated in prospective clinical trials.
优化弥漫性内在脑桥胶质瘤的临床试验需要使用一致、客观的疾病评估和标准化的反应标准。反应评估在儿科神经肿瘤学工作组，由一个国际小组的儿科和成人神经肿瘤学家、临床医生、放射科医生、放射肿瘤学家和神经外科医生组成，旨在解决在评估儿童中枢神经系统肿瘤反应方面的问题和独特挑战。一个工作组是专门成立的，以解决弥漫性内在脑桥胶质瘤儿童和年轻成人的反应评估问题，并就反应评估的建议达成共识。应使用脑和脊柱的 MRI、神经学检查以及抗炎或抗血管生成药物来评估反应。临床成像标准被定义。与以前的共识建议一样，这些建议需要在前瞻性临床试验中进行验证。
